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O22-5 Parental occupational exposures and testicular cancer in offspring: a registry-based case-control study in the nordic countries (nord-test study)
  1. Kayo Togawa1,
  2. Charlotte Le Cornet1,
  3. Maria Feychting2,
  4. Johnni Hansen3,
  5. Eero Pukkala4,5,
  6. Tore Tynes6,7,
  7. Ann Olsson1,2,
  8. Pernilla Wiebert2,
  9. Susanne Oksbjerg Dalton3,
  10. Sanni Uuksulainen8,
  11. Torill Woldbæk7,
  12. Karl-Christian Nordby9,
  13. Niels E Skakkebæk10,
  14. Béatrice Fervers11,12,
  15. Joachim Schüz1
  1. 1Section of Environment and Radiation, International Agency for Research on Cancer, Lyon, France
  2. 2Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  3. 3Danish Cancer Society Research Centre, Copenhagen, Denmark
  4. 4Institute for Statistical and Epidemiological Cancer Research, Finnish Cancer Registry, Helsinki, Finland
  5. 5School of Health Sciences, University of Tampere, Finland
  6. 6Institute of Epidemiological Cancer Research, Cancer Registry of Norway, Oslo, Norway
  7. 7Department of Occupational Health Surveillance, National Institute of Occupational Health, Oslo, Norway
  8. 8Finnish Institute of Occupational Health, Helsinki, Finland
  9. 9Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Oslo, Norway
  10. 10Department of Growth and Reproduction and International Centre for Research and Training, University of Copenhagen, Copenhagen, Denmark
  11. 11Université Claude Bernard Lyon 1, Villeurbanne, France
  12. 12Unité Cancer et Environnement, Centre Léon Bérard, Lyon, France

Abstract

Background Prenatal exposures including parental occupational exposures have been hypothesised to play an etiological role in testicular cancer; however, epidemiological data supporting this hypothesis remain scarce. In the NORD-TEST Study, a registry-based case-control study conducted in the Nordic countries, we examined the associations between certain parental occupational exposures before childbirth and testicular germ cell tumour (TGCT) in offspring.

Methods TGCT cases diagnosed at ages 14–49 years between 1978 and 2012 in Denmark, Finland, Norway, and Sweden were identified from the cancer registries. Four controls per case were randomly selected from the central population registry and matched to cases by country and year of birth. We retrieved information on maternal and paternal occupations before childbirth from census or Pension Fund registry. Using the Nordic job-exposure matrices, occupational information was converted to exposure indices of pesticides (all four countries) and of solvents, heavy metals, or welding fumes (Finland, Norway and Sweden only). Further, information on family history of testicular cancer and personal history of genital malformations were retrieved through registry linkages. Conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI).

Results The study sample comprised 9,569 cases and 32,028 controls (8,112 cases and 26,264 controls excluding Denmark). The data showed no significant associations of TGCT risk with maternal (OR = 0.83, 95% CI: 0.56–1.23) or paternal pesticide exposure (OR = 1.03, 95% CI: 0.92–1.14). We found increased TGCT risk associated with maternal exposure to aromatic hydrocarbon solvents (OR = 1.32, 95% CI: 1.06–1.65) but no linear dose-response relationship. Parental exposures to other solvents, heavy metals, or welding fumes did not significantly increase TGCT risk.

Conclusions The NORD-TEST Study provided little evidence of associations of parental occupational exposures to pesticides, solvents, heavy metals, or welding fumes to TGCT risk, with the possible exception of maternal exposure to aromatic hydrocarbon solvents.

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