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O14-2 Breast cancer and occupational exposures in the mcc-spain study
  1. Gemma Castaño-Vinyals1,2,3,4,
  2. Ana Espinosa1,2,3,4,
  3. Virginia Lope4,5,
  4. Vicente Martín4,6,
  5. Pilar Amiano4,7,
  6. Eva Ardanaz4,8,
  7. Inés Gómez-Acebo4,9,10,
  8. Victor Moreno,
  9. Marian Diaz-Santos11,
  10. Adonina Tardón4,12,
  11. Rosana Peiró4,13,
  12. Rafael Marcos-Gragera4,14,
  13. Miguel Santibáñez15,
  14. Manolis Kogevinas1,2,3,4,
  15. Juan Alguacil4,11
  1. 1CREAL, Barcelona, Spain
  2. 2IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
  3. 3Universitat Pompeu Fabra (UPF), Barcelona, Spain
  4. 4CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
  5. 5Environmental and Cancer Epidemiology Unit, National Centre of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain
  6. 6Universidad de León, León, Spain
  7. 7Subdirección de Salud Pública de Gipuzkoa, Donostia, Spain
  8. 8Instituto de Salud Pública de Navarra, Pamplona, Spain
  9. 15Universidad de Cantabria – IDIVAL, Santander, Spain
  10. 9IDIBELL-Catalan Institute of Oncology, L’Hospitalet de Llobregat, Spain
  11. 10Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
  12. 11Centro De Investigación en Salud y Medio Ambiente (CYSMA), Universidad de Huelva, Huelva, Spain
  13. 12Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain
  14. 13Fundación Para El Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana FISABIO–Salud Pública, Valencia, Spain
  15. 14IDIBGI-Girona Biomedical Research Institute. Catalan Institute of Oncology (ICO), Girona, Spain

Abstract

Introduction The objective is to study the association between occupational exposures and breast cancer risk in the framework of the population based multicase-control study (MCC-Spain).

Methods 1622 breast cancer cases and 1557 population controls from the MCC-Spain study were recruited in 10 Spanish regions between 2008 and 2013. Occupational history was collected for all subjects, and occupations were coded according to the Spanish National Classification of Occupations 1994 (CNO-94). The Spanish Job Exposure Matrix (MatEmESp) was applied to assess occupational exposures to different agents. Unconditional logistic regression was applied, adjusting for age, region, education and menopausal status, showing Odds Ratios and 95% Confidence Intervals (OR; CI).

Results Based on the CNO-94, plastic product workers (OR = 3.4; 1.3–8.5) and occupations related to building caretaking and cleaning (OR = 1.5; 1.2–1.9) have an increase risk in breast cancer. Breast cancer risk was associated with exposure to pesticides (OR = 1.5; 1.1–1.9), organic dusts such as paper dust and wood dust (OR = 1.3, 1.0–1.7), for both menopausal and postmenopausal women. Flour dust was associated overall and specifically for postmenopausal women. Also, welding fumes and exposure to detergents has been observed to increase breast risk. For solvents, associations were observed for formaldehyde, methylene chloride, aromatic hydrocarbons and other organic solvents only in postmenopausal women. Further analyses will be presented taking into account duration and intensity of exposure.

Conclusions Several occupational exposures were associated with an increased risk of breast cancer.

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