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P052 Identifying environmental hazardous substances associated with prostate cancer risk in hong kong population
  1. Lap Ah Tse1,
  2. Chi Fai Ng2,
  3. Wing Ming Ho3,
  4. Ming Yi Priscilla Lee1,
  5. Feng Wang1
  1. 1The Chinese University of Hong Kong, Shatin, China
  2. 2Department of Surgery, Prince of Wales Hospital, Shatin, China
  3. 3Department of Oncology, Prince of Wales Hospital, Shatin, China

Abstract

Objective To identify environmental hazardous substances those are potentially related to the risk of prostate cancer among Hong Kong men.

Methods This is an ongoing case-control study. We are targeting to obtain a total of 400 incident prostate cancer cases and 400 frequency age-matched controls that were consecutively recruited from one public hospital in Hong Kong. Using a standardised questionnaire, we obtained each participant’s socio-demographics, diet and other lifestyle habits, occupational exposures, family cancer histories, and environmental exposure to Bisphenol A Exposure (BPA). Information on BPA exposure of each subject was obtained by collecting the habits of using food and water containers.

Results By November 2015, a total of 360 confirmed prostate cancer incidence cases and 159 hospital controls were recruited and analysed. Compared with the controls, prostate cancer cases had a higher proportion of alcohol drinking (21.4% vs 15.7%) and night shift work (14.9% vs. 6.0%), but they had a relatively low proportion of colleague education or above (12.9% vs. 15.0%). More prostate cancer cases came from poor family (i.e., monthly family income less than USD 516) than the controls (40.1% vs. 29.8%). Based on the current dataset, we did not observe an obvious difference in smoking prevalence and BPA exposure among cases and controls.

Conclusion Our ongoing study identified that alcohol drinking, night shift work, and low socioeconomic status are the potential environmental hazardous factors for the risk of prostate cancer; however, these findings will be updated in the EPICOH2016.

Acknowledgement Health and Medical Research Fund (HMRF), Project No.: 11121091; correspondence: shelly@cuhk.edu.hk

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