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P046 Occupational exposures and gastric cancer risk in the MCC-spain case-control study
  1. Miguel Santibañez1,
  2. Miguel Ángel Alba2,
  3. Juan Alguacil2,3,
  4. Esther Gracia3,4,
  5. Laura Costas3,5,
  6. Jose Antonio Garrido2,
  7. Nuria Aragonés3,6,7,
  8. Beatriz Pérez-Gómez3,6,7,
  9. Antonio José Molina8,9,
  10. Tania Fernández8,9,
  11. Javier Llorca1,3,
  12. Victor Moreno3,5,10,
  13. Jone M Altzibar3,11,
  14. Eva Ardanaz3,12,
  15. Silvia de Sanjosé3,5,
  16. José Juan Jiménez-Moleón3,13,14,
  17. Adonina Tardón3,15,
  18. Rocío Capelo2,
  19. Rosana Peiró3,16,
  20. Rafael Marcos-Gragera17,
  21. Carmen Navarro3,18,19,
  22. Gemma Castaño3,4,20,21,
  23. Marina Pollán3,6,7,
  24. Ana Maria García3,22,
  25. Manolis Kogevinas3,4,20,21,23
  1. 1University of Cantabria-Instituto De Investigación Marqués De Valdecilla (IDIVAL) -Marqués De Valdecilla Research Institute (IDIVAL), Santander, Spain
  2. 2University of Huelva-Centro De Investigación en Salud Y Medio Ambiente (CYSMA), Huelva, Spain
  3. 3CIBER Epidemiología Y Salud Pública (CIBERESP), Madrid, Spain
  4. 4Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
  5. 5IDIBELL-Catalan Institute of Oncology, L’Hospitalet De Llobregat, Spain
  6. 6National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
  7. 7Instituto De Investigación Sanitaria (IIS) Puerta De Hierro, Majadahonda, Spain
  8. 8The Research Group in Gene – Environment and Health Interactions, University of León, León, Spain
  9. 9Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, University of León, León, Spain
  10. 10Department of Clinical Sciences, University of Barcelona, Barcelona, Spain
  11. 11Subdirección De Salud Pública De Gipuzkoa, Donostia, Spain
  12. 12Instituto De Salud Pública De Navarra, Pamplona, Spain
  13. 13Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
  14. 14Instituto De Investigación Biosanitaria De Granada, Servicio Andaluz De Salud/Universidad De Granada, Granada, Spain
  15. 15Oncology Institute (IUOPA), University of Oviedo, Oviedo, Spain
  16. 16Fundación Para El Fomento De La Investigación Sanitaria Y Biomédica De La Comunitat Valenciana FISABIO–Salud Pública, Valencia, Spain
  17. 17Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), Girona, Spain
  18. 18Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain
  19. 19Department of Health and Social Sciences, Universidad De Murcia, Murcia, Spain
  20. 20Universitat Pompeu Fabra (UPF), Barcelona, Spain
  21. 21Hospital Del Mar Medical Research Institute (IMIM), Barcelona, Spain
  22. 22Department of Preventive Medicine and Public Health, University of Valencia, Valencia
  23. 23National School of Public Health-Greece, Athens, Greece

Abstract

Objective To explore the relationship between gastric cancer (GC) and occupational exposures.

Methods A total of 382 incident GC cases and 2,846 randomly selected population controls with occupational information were included from the MCC-Spain study, a population-based multicase-control study. Occupation was coded according to the Spanish National Classification of Occupations 1994. Occupational exposures were assessed by the MatEmEsp Job Exposure Matrix. ORs and their 95% confidence intervals (CI) were estimated by unconditional logistic regression adjusting for matching variables and education.

Results In men, a statistically significant increased risk of GC, was found for ‘Employed skilled workers in agricultural activities’ (OR 4.4) and a borderline association was found for ‘miners and quarry workers’ (OR 1.8, 95% CI: 0.9 to 3.4). Regarding occupational exposures, a statistically significant association was found for long term exposure (>10 years) to ‘insecticides’ in women (OR 2.68) and a borderline association was found in men (OR 1.43, 95% CI: 0.94 to 2.17). In men, a statistically significant increased risk of GC for the highest level of exposure to ‘ioninzing radiation’ (2.08), and ‘silica dust’ (OR1.52) was also found. In women, statistically significant associations were found for the highest level of exposure to some dusty exposures such as ‘flour dust’ (OR 1.76), or ‘other mineral dust different from silica’ (OR 2.07). A borderline association was found in women for other dusty exposures such as ‘paper pulp&dust’ (OR 3.22, 95% CI: 0.99 to 10.45), and non-significant increases of risk were found for ‘leather dust’ (OR 2.30, 95% CI: 0.58 to 9.17) and ‘textile dust’ (OR 2.30, 95% CI: 0.59 to 9.92).

Conclusions This study supports the relationship previously suggested between GC and ionising radiation, pesticides or occupational exposure to dusty environments.

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