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P045 Occupational exposure and prostate cancer in the multicase-control study in spain (MCC-„spain)
  1. Jose Manuel Ruiz Domínguez1,
  2. Ana Espinosa Morano1,2,3,4,
  3. Gemma Castaño-Vinyals1,2,3,4,
  4. Beatriz Perez-Gómez4,5,6,
  5. Trinidad Dierssen-Sotos,
  6. Rosana Peiró,
  7. José Juan Jiménez-Moleón,
  8. Rocío Capelo,
  9. Adonina Tardón,
  10. Jose Antonio Garrido,
  11. Manolis Kogevinas,
  12. Juan Alguacil10,4
  1. 1Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
  2. 2IMIM (Hospital Del Mar Medical Research Institute), Barcelona, Spain
  3. 3Universitat Pompeu Fabra (UPF), Barcelona, Spain
  4. 4CIBER Epidemiología Y Salud Pública (CIBERESP), Madrid, Spain
  5. 5Environmental and Cancer Epidemiology Unit, National Centre of Epidemiology, Instituto De Salud Carlos III, Madrid, Spain
  6. 6IIS Puerta De Hierro, Madrid, Spain
  7. 7Universidad De Cantabria – IDIVAL, Santander, Spain, Santander, Spain
  8. 8Fundación Para El Fomento De La Investigación Sanitaria Y Biomédica De La Comunitat Valenciana FISABIO–Salud Pública, Valencia, Spain
  9. 9Instituto De Investigación Biosanitaria De Granada (Ibs.GRANADA), Hospitales Universitarios De Granada/Universidad De Granada, Granada, Spain
  10. 10Centro De Investigación en Salud Y Medio Ambiente (CYSMA), Universidad De Huelva, Huelva, Spain
  11. 11Instituto Universitario De Oncología, Universidad De Oviedo, Oviedo, Spain

Abstract

Background In Spain, prostate cancer is the third cause of mortality from cancer in men, after lung and colorectal cancers. Age, family history and race are common risk factors. Several environmental and occupational factors have been investigated, including pesticides and endocrine disruptors, but results are inconsistent. We have previously shown an association of prostate cancer risk with shift work. We evaluate here which occupations and agents are associated with a high risk for prostate cancer within the framework of the MCC-Spain.

Methods We included 1111 incident cases of prostate cancer and 1489 population controls recruited from 7 Spanish regions from September 2008 to December 2012. Occupational history was collected for all subjects, and occupations were coded according to the Spanish National Classification of Occupations 1994 (CNO-94). The Spanish Job Exposure Matrix (MatEmESp) was applied to assess occupational exposures to different agents. Unconditional logistic regression was applied, adjusting for age, education and region, showing Odds Ratios and 95% Confidence Intervals (OR; CI).

Results Construction building managers (OR = 2.0; 1.1–3.8), cleaning personnel (OR = 2.1; 1.1–4.0), farmers (OR = 3.0; 1.1–8.1) were associated with an increase risk in prostate cancer. An association has been observed for exposure to inorganic dust, specifically to silica dust (OR = 1.3; 1.1–1.7), insecticides (OR = 1.4; 1.1–1.8), and ultraviolet radiations (OR = 1.3; 1.1–1.6). Analysis on intensity and duration of the exposure to certain agents as well as associations with extension of the disease will be presented.

Conclusions Occupational exposures may play a role in the development of prostate cancer.

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