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P038 Cancer incidence in the agrican cohort study (2005–2011)
  1. Clémentine Lemarchand1,2,3,
  2. Séverine Tual1,2,3,
  3. Noémie Levêque-Morlais1,2,3,
  4. Stéphanie Perrier1,2,3,
  5. Aurélien Belot4,
  6. Michel Velten5,
  7. Anne-Valérie Guizard6,
  8. Elisabeth Marcotullio7,
  9. Alain Monnereau8,9,
  10. Bénédicte Clin1,2,10,
  11. Isabelle Baldi9,11,
  12. Pierre Lebailly1,2,3
  1. 1U 1086 Cancers Et Préventions, Caen, France
  2. 2Université De Caen Normandie, Caen, France
  3. 3Centre De Lutte Contre Le Cancer François Baclesse, Caen, France
  4. 4London School of Hygiene and Tropical Medicine, London, UK
  5. 5Registre Des Cancers Du Bas-Rhin, Faculté De Médecine, Université De Strasbourg, Strasbourg, France
  6. 6Registre Général Des Tumeurs Du Calvados, Centre François Baclesse, Caen, France
  7. 7Caisse Centrale De La Mutualité Sociale Agricole, Bagnolet, France
  8. 8Registre Des Hémopathies Malignes De La Gironde, Bordeaux, France
  9. 9INSERM, ISPED, EPICENE Team – Centre INSERM U 1219 – Bordeaux Population Health Centre, Bordeaux, France
  10. 10CHU De Caen, Service De Pathologie Professionnelle, Caen, France
  11. 11CHU De Bordeaux, Service De Médecine Du Travail, Bordeaux, France

Abstract

Introduction Agricultural populations tend to have lower rates of mortality than in the general population but farming exposures have been regularly associated with an increased risk of some cancers. Our aim was to evaluate cancer incidence in the AGRICAN cohort.

Methods AGRICAN is a prospective cohort including 181,842 active and retired, male and female participants, affiliated for at least 3 years to the French agricultural health insurance, and living in one of the 11 areas covered by a cancer registry at the time of enrolment. Incident cancers were identified through linkage with cancer registries from enrolment (2005–2007) to 2011. Age and sex standardised incidence Ratios (SIRs) were calculated for comparison with the general population of each area.

Results A total of 11,067 incident cancer cases (7,304 men, 3,763 women) were identified. Overall cancer incidence was comparable in the cohort and in the general population. However, SIRs were significantly reduced for tobacco-related cancers (respiratory and urinary cancers) and conversely significant excesses were observed for i) multiple myeloma both in men (SIR = 1.38) and in women (SIR = 1.26), ii) skin melanoma (SIR = 1.23) among women, iii) prostate cancer (SIR = 1.07) and iv) non-Hodgkin lymphoma (SIR = 1.09) among men. Lip cancer incidence was also elevated among men (SIR = 1.38). Stratified analyses showed differences between farm workers and farm owners. Pesticide users had a greater incidence of lip cancer and multiple myeloma among men and skin melanoma among women.

Conclusion We found no overall difference between cancer incidence in the cohort and the general population but an increased incidence of prostate and lip cancers, skin melanoma and multiple myeloma. Stratified analyses made it possible to identify sub-groups of specific interest with a higher cancer incidence related to professional status and pesticide use.

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