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P032 Occupational solvent exposure and risk of bladder cancer in the nordic countries
  1. Kishor Hadkhale1,
  2. Jan Ivar Martinsen2,
  3. Elisabete Weiderpass2,3,4,5,
  4. Kristina Kjaerheim2,
  5. Elsebeth Lynge6,
  6. Pär Sparen5,
  7. Laufey Tryggvadottir7,
  8. Eero Pukkala1,8
  1. 1University of Tampere, School of Health Sciences, Tampere, Finland
  2. 2Cancer Registry of Norway, Department of Research, Institute of Population-Based Cancer Research, Oslo, Norway
  3. 3University of Tromsø, Arctic University of Norway, Department of Community Medicine, Faculty of Health Sciences, Tromsø, Norway
  4. 4Folkhälsan Research Centre, Genetic Epidemiology Group, Helsinki, Finland
  5. 5Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden
  6. 6University of Copenhagen. Institute of Public Health, Centre for Epidemiology and Screening, Denmark
  7. 7Icelandic Cancer Registry, Reykjavik, Iceland
  8. 8Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland

Abstract

Introduction Bladder cancer risk is suggested to vary between occupational categories. We assessed the occupational variation in incidence of bladder cancer and relationship with chemical solvent exposures in the Nordic countries.

Methods The study is based on Nordic Occupational Cancer Study (NOCCA). Data consist of 14.9 million individuals of age 30 to 64 years from the Nordic countries who participated in one or more population censuses since 1960 and were followed up for 45 years. During the follow-up 148,669 cases of bladder cancer were detected. Standardised incidence ratio with 95% of confidence interval (CI) was used to describe the variation in bladder cancer risk in comparison to the national average. Quantitative estimates of solvents exposure for 113,343 bladder cancer cases and 566,715 population controls were assigned using Nordic job exposure matrix. Hazard ratios (HR) and 95% CI: for each solvent was estimated using conditional logistic regression.

Results Highest statistically significant risks were observed among tobacco workers (SIR 1.57, 95% CI: 1.24–1.96), chimney sweeps (1.48, 1.21–1.80), waiters (1.43, 1.33–1.53), hairdressers, seamen, printers, plumbers. Significant decreased risks were observed among farmers (0.70, 0.68–0.71) and forestry workers (0.74, 0.70–0.78). Significantly increasing trends in SIR over the years were observed among drivers and launderers. The occupational risk associated with the chemical solvent at highest exposure levels (>90th percentile of the exposed persons) were aliphatic and alicyclic hydrocarbon solvent (HR 1.08, 95% CI: 1.00–1.23), benzene (1.16, 1.04–1.31), toluene (1.20, 1.00–1.38) and trichloroethylene (1.23, 1.12–1.40).

Conclusion Occupation is evidently associated with bladder cancer risk. Part of that variation appears to be attributable to solvent exposures.

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