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P028 Risk of lymphoma subtypes and occupational exposure to organic dust
  1. Pierluigi Cocco1,
  2. Fahad Ahmed2,
  3. Tinucia Nonne1,
  4. Giannina Satta1,
  5. Carlo Aresti1,
  6. Alessandra Argiolas1,
  7. Luigi Lecca1,
  8. Federico Marras1,
  9. Nicola Mascia1,
  10. Marcello Noli1,
  11. Sergio Pili1,
  12. Ilaria Pilia1,
  13. Roberto Loscerbo1,
  14. Tiziana Serra1,
  15. Diego Serraino1,
  16. Michela Ursi1,
  17. Nikolaus Becker3,
  18. Silvia De Sanjosé4,
  19. Lenka Foretova5,
  20. Marc Maynadié6,
  21. Alexandra Nieters7,
  22. Anthony Staines8,
  23. Emanuele Angelucci9,
  24. Attilio Gabbas1,
  25. Marco Rais1,
  26. Maria Grazia Ennas1
  1. 1University of Cagliari, Monserrato, Italy
  2. 2Hacettepe University, Ankara, Turkey
  3. 3German Cancer Research Centre, Heidelberg, Germany
  4. 4Catalan Institute of Oncology, Barcelona, Spain
  5. 5Masaryk University, Brno, Czech Republic
  6. 6Dijon University Hospital, Dijon, France
  7. 7University of Freiburg, Freiburg, Germany
  8. 8Dublin City University, Dublin, Ireland
  9. 9Local Health Unit N. 8, Cagliari, Italy

Abstract

Background Exposure to high molecular weight agents, such as those associated with organic dust, has shown an inverse association with lymphoma risk. In this paper, we used the data base of the multicentre European case-control study EPILYMPH to explore risk of lymphoma subtypes associated with occupational exposure to six different types of organic dust.

Methods During 1998–2004, a case-control study on the aetiology of lymphoma was conducted in six European countries. Overall, assessment of exposure to organic dust was completed in 1941 cases and 1992 controls. Risk of the major lymphoma subtypes associated with exposure to any organic dust, flour dust, hardwood, softwood, leather and natural and artificial textile fibres was calculated with unconditional logistic regression analysis, adjusting by age, gender, education and study centre.

Results Risk of B-cell lymphoma associated with exposure to any organic dust was inverse (OR = 0.6, 95% CI: 0.3–1.0), with a significant inverse trend by duration and intensity of exposure. The inverse association was strongest for exposure to flour and wood dust, independent on whether hardwood or softwood. The inverse association was likewise observed ifor diffuse large B cell lymphoma, follicular lymphoma, and chronic lymphocytic leukaemia.

Conclusions Our results appear to confirm an inverse association of risk of the major lymphoma subtypes with exposure to organic dust, and aprticularly with flour dust and wood dust.

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