Occupational exposure to heat can affect the absorption of carcinogenic chemicals into the body, and the metabolism of sexual hormones. We explored the association between occupational exposure to heat and breast, chronic lymphocytic leukaemia, colorectal, prostate, and stomach cancer in the MCC-Spain population based case-control study.
Methods The analyses were based on 3047 controls, and 1499 breast, 1539 colorectal, 332 LLC, 1070 prostate, and 382 stomach cancer cases. Heat working environment from either natural or artificial sources was assessed with the MatEmEsp job-exposure matrix. Logistic regression models accounting for education, sex, geographic area, BMI (colorectal, prostate), smoking (stomach, colorectal), menopause (breast) and number of alive children (breast) were fit to estimate Odds Ratios (OR) and 95% Confidence Limits (95 CL).
Results Prostate cancer risk was over two and a half fold higher among men working for more than 10 years on a heat working environment than among who did not. Women working more than 10 years in occupations entailing heat exposure showed a higher risk of having breast cancer (OR: 1.3, 95% CL 1.04–1.7). The same figures where obtained for those working in occupations with higher probability*intensity of the exposure. Significant higher risk associations were also observed for colorectal cancer, among both men and women separately. While for stomach cancer, statistical significance was obtained only among men. LLC showed a suggestion of an association for both men and women.
Our results provide further support to the hypothesis that working in a heat environment might be a risk factor for chemically and hormone related cancers.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.