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0240 Acute Effects of Occupational Noise Exposure on 24-Hour Ambulatory Cardiac Parameters in Workers
  1. Ta-Yuan Chang1,
  2. Ya-Yun Wu1,
  3. Ven-Shing Wang1,
  4. Chang-Chuan Chan2,
  5. Chiu-Shong Liu3
  1. 1China Medical University, Taichung, Taiwan
  2. 2National Taiwan University, Taipei, Taiwan
  3. 3China Medical University Hospital, Taichung, Taiwan

Abstract

Objectives Exposure to noise has been associated with cardiovascular disease, but the mechanism related to cardiac activity is unknown. This repeated-measure study aimed to investigate effects of occupational noise exposure on 24-hour ambulatory cardiac parameters among aviation industry workers.

Method We recruited 75 volunteers in an aircraft-manufacturing industrial cohort in 2009. Individual noise exposure and personal cardiac parameters, including left ventricular contractility (LVC) and stroke volume (SV), were measured simultaneously over 24 h on working and non-working days. Linear mixed-effects regressions were used to determine transient and sustained effects on ambulatory LVC and SV among high-exposure (≥ 80 A-weighted decibel [dBA]), low-exposure (< 80 dBA) and office workers by controlling for potential confounders.

Results Per 1-dBA increase was significantly associated with the transient effects of -1.50 (95% confidence interval [CI]: -2.166, -1.024) ml/beat in SV and -1.75 (-2.95, -1.03) L/sec in LVC at work on working day only among high-exposure workers. Such decreasing effects on SV (-1.18 [-2.86, -1.09] ml/beat) and LVC (-2.22, [-4.43, -1.11] L/sec) still persisted in the 30-min time-lagged occupational noise exposure. We also found that 1-dBA increment in 24-hour average noise exposure was significantly associated with a sustained decrease of -1.19 (-1.25, -1.13) ml/beat in SV on working day among high-exposure workers. No significant effects were found among other groups on working day and among all groups on non-working day.

Conclusions Occupational noise exposure may have acute effects on 24-hour ambulatory cardiac parameters among workers. Such effects may be associated with the development of cardiovascular disease.

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