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0181 Associations between pre-defined occupational job tasks and breast cancer risk
  1. Sylvia Rabstein1,
  2. Beate Pesch1,
  3. Volker Harth2,
  4. Christina Justenhoven3,
  5. Ute Hamann4,
  6. Hiltrud Brauch3,
  7. Yon Ko5,
  8. Thomas Bruening1
  1. 1Institute of Prevention and Occupational Medicine, German Social Accident Insurance (IPA), Bochum, Germany
  2. 2Institute for Occupational Medicine and Maritime Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
  3. 3Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany
  4. 4Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
  5. 5Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter-Krankenhaus Bonn, Bonn, Germany


Objectives The role of occupational exposures in agricultural and industrial settings has been addressed in several breast cancer studies. Recently, the influence of shift work in nurses added as an occupational hazard that has been intensively discussed. Here, we investigate the association of job tasks in the industrial and health sector and breast cancer in a large case-control study.

Method The population-based case-control study Gene-ENvironment Interaction and Breast CAncer (GENICA) was conducted in the Greater Region of Bonn, Germany. Occupational history and job task information were collected in computer-assisted interviews. Thirty pre-defined job tasks were assessed for 1143 cases and 1155 controls in addition to the occupational history. Risk estimates were calculated as odds ratios (ORs) with 95% confidence intervals (CIs) conditional on age and adjusted for potential confounders.

Results First preliminary results indicate an increased age-adjusted risk for women who ever worked in anaesthesia (OR 1.87; 95% CI 1.03–8.0), based on fourteen cases and five controls.

Conclusions Our study revealed an increased risk for ever working in anaesthesia. This elevated risk might origin from chemical exposures or night shift work. Interactions between exposures and night work might be relevant in the progression of breast cancer. However, the results of this study are limited by the low prevalence of risk jobs and specific exposures.

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