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0408 PubMed search strings for the study of putative environmental determinants of disease
  1. Stefano Mattioli1,
  2. Davide Gori2,
  3. Valentina Di Gregori2,
  4. Andrea Farioli1,
  5. Maria Pia Fantini2,
  6. David Christiani3,
  7. Stefania Curti1,
  8. Francesco Violante1
  1. 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
  2. 2Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
  3. 3School of Public Health, Harvard University, Harvard, USA


Objectives Several optimised search strategies have been developed in Medicine, and more recently in Occupational Medicine. Aim of this study is to identify efficient PubMed search strategies for the study of putative environmental determinants of a disease.

Method We compiled a list of search terms (either Medical Subjects Heading [MeSH] or non-MeSH) seeming pertinent to exposure to pollutants as determinants of diseases in general population. We estimated proportions of potentially pertinent articles to formulate two search strategies (one “more specific”, one “more sensitive”). We applied these strategies to retrieve information on the putative environmental determinants of three diseases: autoimmune disease, sudden death and congenital heart defects. We evaluated the number of needed to read (NNR) abstracts to identify one potentially pertinent article in the context of these pathologies.

Results The “more specific” search string was based on the combination of terms that yielded the highest proportion (≥ 40%) of potentially pertinent abstracts, including the MeSH terms ‘air pollutants’,air pollution’, ‘disorders of environmental origin’, ‘environmental exposure’ and ‘particulate matter’. The “more sensitive” string was based on use of broader search fields and additional coverage provided by other search terms under study. Using the “more specific” string, the NNR to find one potentially pertinent article were: 2.7 for autoimmune disease; 3.2 for sudden death; 1.1 for congenital heart defects. Using the sensitive strategy, the NNR were 4.0, 6.1 and 3.4, respectively.

Conclusions The proposed strings could help health care professionals investigate environmental determinants of medical conditions that could be related to pollution.

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