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143 Persistent Rotating Shift Work Is a Second Hit Contributing to Abnormal Liver Function among On-Site Workers Having Fatty Liver
  1. P C Chen1,
  2. Y C Lin2
  1. 1National Taiwan University, Taipei, Taiwan
  2. 2En Chu Kong Hospital, New Taipei, Taiwan


Objective To investigate the relationship between elevated serum alaninetransaminase (ALT) and persistent rotating shift work (p-RSW) among employees with sonographic fatty liver (SLF).

Methods The authors performed a retrospective analysis on a cohort of electronics manufacturing workers. The records of 758 workers (507 males, 251 females) with initially normal ALT and a mean age of 32.9 years were analysed.

Results A total of 109 workers (14.4%) developed elevated ALT (e-ALT) after five years. Compared with those having neither initial SFL nor p-RSW exposure, multivariate analysis indicated that employees who had initial SFL but without p-RSW finally had a higher risk (odds ratio: 2.9; 95% confidence interval (CI): 1.7–5.1) for developing e-ALT; workers with baseline SFL plus p-RSW had a 3.7-fold increased risk (95% CI: 1.8–7.5).

Conclusions SFL poses a conspicuous risk for the development of e-ALT, and persistent p-RSW exposure significantly aggravates the development of e-ALT among on-site workers with preexisting SLF.

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