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111 Production of IL-10, TNF and IL-12 by Peripheral Blood Mononuclear Cells in Mexican Workers Exposed to a Mixture of Benzene-Toluene-Xylene
  1. L H Haro-Garcìa1,
  2. C A J P Juárez-Pérez2,
  3. G A M Aguilar-Madrid2,
  4. N V Z Vélez-Zamora2,
  5. S M Muñoz-Navarro3,
  6. R C H S Chacón-Salinas4,
  7. C R G B González-Bonilla2,
  8. C R I H Iturbe-Haro4,
  9. I E G Estrada-García4,
  10. V H Borja-Aburto2
  1. 1Universidad Autònoma de la Ciudad de Mèxico, Delegaciòn Cuauhtèmoc, Cd. de Mèxico, Mexico
  2. 2Instituto Mexicano del Seguro Social, Mexico City, Mexico
  3. 3Universidad de la Frontera, Temuco, Chile
  4. 4Instituto Politécnico Nacional, Mexico City, Mexico

Abstract

Objective To determine relationship between occupational exposure to benzene-toluene-xylene mixture (BTX) and IL-10, TNF and IL-12 production by peripheral blood mononuclear cells.

Methods Exposure was estimated in 54 workers from a paint company in Mexico City through BTX accumulated potential dose (BTX-APD). Two exposure groups were formed: high and low BTX-APD established with a cutoff point at ≥1.0 of BTX-APD, as a function of the geometric mean of the estimator’s value distribution and the higher agreement between BTX-APD ≥1.0 and the areas referred as using (or not) organic solvents in the work process. IL-10, TNF and IL-12 concentrations were measured with ELISA. Through multiple linear regression models, the production of each of the proposed cytokines and of the whole set was assessed.

Results Workers with high BTX-APD showed a significant reduction in TNF production (β = -1,196.0 pg/mL; p = 0.01); a reduction for IL-10 (β = -520.3; p = 0.13) and IL-12 (β = -843.3; p = 0.09) was also observed, although without statistical significance.

Conclusions TNF production assessed in workers with a high BTX-APD is lower than in those with a low BTX-APD, but not in IL-10 and IL-12 production.

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