Article Text

PDF

106 Cancer incidence and mortality in agricultural cohorts in the AGRICOH consortium
  1. R E Denholm1,
  2. Beane Freeman2,
  3. Schüz1,
  4. Alavanja2,
  5. MacFarlane3,
  6. Sim3,
  7. Lebailly4,
  8. Baldi5,
  9. Kjaerheim6,
  10. Langseth6,
  11. Nordby7,
  12. Park8,
  13. Yoo8,
  14. Keifer9,
  15. Waring10,
  16. Ferro1,
  17. Douwes11,
  18. Hoppin12,
  19. Kromhout13,
  20. Schenker14,
  21. Leon1
  1. 1International Agency for Research on Cancer, Lyon, France
  2. 2National Cancer Institute, Bethesda, Maryland, United States of America
  3. 3Monash University, Victoria, Australia
  4. 4Université de Caen Basse-Normandie, Caen, France
  5. 5Universite Bordeaux 2, Bordeaux, France
  6. 6The Cancer Registry of Norway, Oslo, Norway
  7. 7National Institute of Occupational Health, Oslo, Norway
  8. 8Seoul National University College of Medicine, Seoul, South Korea
  9. 9National Farm Medicine Center, Marshfield, Wisconsin, United States of America
  10. 10Essentia Institute of Rural Health, Duluth, Missesota, United States of America
  11. 11Massey University, Wellington, New Zealand
  12. 12National Institute of Environmental Health Sciences, North Carolina, United States of America
  13. 13Utrecht University, Utrecht, Nederland
  14. 14University of California at Davis, Davis, California, United States of America

Abstract

Objectives Farmers have different cancer incidence and mortality patterns than the general population, with excesses of some cancers (e.g., lymphoma, multiple myeloma, brain, skin and prostate), and lower risk of others (e.g., lung). AGRICOH, a consortium of 27 cohort studies in agricultural populations, was formed to investigate the impact of specific occupational, environmental and lifestyle factors on health outcomes in farming populations. This study aims to describe the cohort-specific cancer incidence and mortality rates in AGRICOH studies with cancer information.

Methods Outcome data have been obtained from linkage to cancer and mortality registries. Person-years of follow-up contributed by each participant will be calculated and grouped into 5-year age intervals and calendar years. Crude and age- and gender- standardised incidence and mortality rates will be estimated for each cohort, for all cancers, individual cancer sites and, where possible, specific histological subtypes. Rates will be stratified by participant’s relationship to the farm (farmer, spouse) and primary commodity produced (crop, livestock or both).

Results Seven AGRICOH cohorts with cancer data have agreed to participate (n = 315,298). These cohorts represent Australia (Pesticide Exposed Workers & Victorian Grain Farmers), France (Agriculture & Cancer), Korea (Korean Multi-Center Cancer), Norway (Cancer in the Norwegian Agricultural Population), and USA (United States Agriculture Health Study & The Marshfield Epidemiology Study Area Farm Cohort). Target populations vary between studies and include active and retired agricultural workers, farm owners and their families, and agricultural groups exposed to specific agents.

Conclusions Comparing and contrasting patterns of cancer incidence and mortality in studies from around the world with different agricultural practices and populations will generate hypotheses for future data-pooling projects. In particular, the study will identify cancers of high priority in agricultural workers and provide hypotheses on potential causes for differences in rates between populations, or on common exposures that might contribute to similarities.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.