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391 Association between occupational exposure to wood dust and risk of nasopharyngeal cancer: A case-control study from Thailand
  1. S S Sangrajrang1,
  2. Ekburanawat2,
  3. Ekpanyasakul3,
  4. Thetkathek4,
  5. Saejew5,
  6. Ruangsuwan6,
  7. T Mannetje7
  1. 1National Cancer Institute, Bangkok, Thailand
  2. 2Nopparat Rajthanee Hospital, Bangkok, Thailand
  3. 3Srinakarinwirot University, Bangkok, Thailand
  4. 4Burapa University, Chonburi, Thailand
  5. 5Walailak University, Nakhon Si Thammarat, Thailand
  6. 6South-East Asia University, Bangkok, Thailand
  7. 7Massey University, Wellington, New Zealand

Abstract

Objectives To explore possible association between occupational wood dust exposure and risk of nasopharyngeal cancer (NPC), a matched case - control study was conducted in Bangkok and 6 regional cancer treatment centers in Thailand.

Methods Three hundred and twenty-seven diagnosed NPC cases were compared with 327 age and gender matched controls. Data of socio-demographic characteristics and potential risk factors were collected by personal interviews. Wood dust exposures were assessed by 3 industrial hygienists by reading lifetime occupational histories of the participants with unknown for case-control status. Assessments were done for probability, frequency and intensity of exposure to wood dust. Multivariate analyses were performed adjusting for educational level, smoking status and histories of chronic sinusitis.

Results We found the association between occupational wood dust exposure and NPC risk (OR 1.66, 95% CI 1.03 - 2.67) especially for those who have definite probability of exposure (OR 1.77, 95% CI 1.04 - 3.00), moderate frequency of exposure (OR 2.8, 95% CI 1.22 - 6.39) and low intensity of exposure (OR 2.29, 95% CI 1.15 - 4.59).

Conclusion Results of this study shows that occupational exposure to wood dust are likely to be associated with increasing risk of NPC.

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