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379 Occupational exposure to trichloroethylene and risk of non-Hodgkin lymphoma and its major subtypes: a pooled interlymph analysis
  1. P C Cocco1,
  2. Vermeulen2,
  3. Flore1,
  4. Nonne1,
  5. Campagna1,
  6. Purdue3,
  7. Blair3,
  8. Monnereau4,
  9. Orsi5,
  10. Becker6,
  11. De Sanjosé7,
  12. Foretova8,
  13. Staines9,
  14. Maynadié10,
  15. Nieters11,
  16. Miligi12,
  17. ’t Mannetje13,
  18. Brennan14,
  19. Lan3,
  20. Rothman3
  1. 1University of Cagliari, Monserrato, Italy
  2. 2Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
  3. 3Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, United States of America
  4. 4Centre régional de lutte contre le cancer, Institut Bergonié, Bordeaux, France
  5. 51. Institut National de la Santé et de la Recherché Médicale, Villejuif, France
  6. 6German Cancer Research Center, Heidelberg, Germany
  7. 7Unit of Infections and Cancer, ICO and CIBERESP, Barcelona, Spain
  8. 8Department of Cancer Epidemiology and Genetics, Brno, Czech Republic
  9. 9School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland
  10. 10Dijon University Hospital, Dijon, France
  11. 11Centre of Chronic Immunodeficiency, University of Freiburg, Freiburg, Germany
  12. 12SPO Cancer Prevention and Research Institute, Florence, Italy
  13. 13Centre for Public Health Research, Massey University, Wellington, New Zealand
  14. 14International Agency for Research on Cancer, Lyon, France

Abstract

Objectives To test the association between occupational exposure to trichloroethylene (TCE) and risk of non Hodgkin lymphoma (NHL), we conducted a pooled analysis of four international case-control studies.

Methods Studies were selected which included state-of-the art retrospective assessment of occupational exposure to TCE and histological information on lymphoma subtype. Overall, the pooled study population included 3788 NHL cases and 4279 controls. Summary indicators of exposure were harmonised across studies. We conducted unconditional logistic regression analysis to test the association between the harmonised TCE exposure estimates and NHL and its major subtypes, adjusting by age, gender, and study.

Results Among the total study population, risk of follicular lymphoma, but not NHL overall or other subtypes, increased by probability (p = 0.02) and intensity level (p = 0.04) of TCE exposure. When the analysis was restricted to subjects most likely exposed to TCE, risk of NHL overall (p = 0.009), follicular lymphoma (p = 0.04), and chronic lymphocytic leukaemia (CLL) (p = 0.01) showed a linear increase by duration of exposure. No heterogeneity in NHL risk associated with high probability of exposure to TCE (all intensity levels combined) was detected.

Conclusion With due caution because of several limitations, our pooled analysis supports the hypothesis of an increased risk of NHL, and particularly of the follicular lymphoma and CLL subtypes, associated with occupational exposure to TCE.

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