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Original article
Occupational asthma and occupational rhinitis: the united airways disease model revisited
  1. Jacques Ameille1,2,
  2. Karine Hamelin2,
  3. Pascal Andujar3,
  4. Lynda Bensefa-Colas4,
  5. Vincent Bonneterre5,
  6. Dominique Dupas6,
  7. Robert Garnier7,
  8. Brice Alain Loddé8,
  9. Mickael Rinaldo9,
  10. Alexis Descatha1,
  11. Gérard Lasfargues10,
  12. Jean-Claude Pairon3,
  13. the members of the rnv3p
  1. 1AP-HP, Occupational Health Department, Raymond Poincaré hospital, Garches, France
  2. 2Institut interuniversitaire de médecine du travail, Paris, France
  3. 3INSERM U 955, and Occupational Health Department, Créteil, France
  4. 4AP-HP, Occupational Health Department, Cochin hospital, Paris, France
  5. 5UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France
  6. 6Occupational Health Department, University Hospital, Nantes, France
  7. 7AP-HP, Occupational Health Department, Fernand-Widal Hospital, Paris, France
  8. 8Occupational Health Department, University Hospital, Brest, France
  9. 9Occupational Health Department, University Hospital, Bordeaux, France
  10. 10Agence nationale de sécurité sanitaire, Maisons-Alfort, France
  1. Correspondence to Professor Jacques Ameille, AP-HP, Occupational Health Department, Unité de pathologie professionnelle, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, Garches 92380, France; jacques.ameille{at}rpc.aphp.fr

Abstract

Objectives Whereas accumulating evidence indicates close associations between rhinitis and asthma, little is known about the relationships between occupational rhinitis (OR) and occupational asthma (OA). This study analyses the prevalence of OR associated with OA, globally and according to the various causal agents, and investigates the temporal relationships between these two conditions.

Methods Data on incident cases of OA (2008–2010) were collected through the French national occupational disease surveillance and prevention network, using a standardised form including information on occupation, causal agents, presence of OR, and respective dates of occurrence of rhinitis and asthma.

Results Among the 596 reported OA cases with latency period, 555 could be attributed to identified agents: high molecular weight (HMW) agents (n=174); low molecular weight (LMW) agents (n=381). Overall, OR was associated with OA in 324 (58.4%) cases. The frequency of association was significantly higher for HMW agents than for LMW agents (72.2% vs 51.5%, p<0.001). OR occurred before OA significantly more frequently for HMW agents than for LMW agents (p<0.01).

Conclusions These results show that OR is frequently associated with OA, especially when HMW agents are involved. They are consistent with the hypothesis that OR, in conjunction with OA, is more likely to be caused by sensitisers that cause disease via IgE-mediated mechanisms and suggest that symptoms of OR should be taken into account in the medical surveillance of workers exposed to HMW agents.

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