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Reproductive effects 1
Time to pregnancy study in male workers exposed to carbon disulfide in the rayon industry
  1. Kuang-Yi Chang1,
  2. Ching-Chun Lin1,
  3. Tung-Sheng Shih2,
  4. Pau-Chung Chen1
  1. 1NTU, Taipei, Taiwan
  2. 2Institute of Occupational Safety and Health, Taipei, Taiwan


Objectives The aim of study was to investigate whether exposure to carbon disulfide (CS2) has an impact on couple fecundability.

Methods A total of 56 male workers in the rayon industry were recruited in this retrospective cohort study. We used time to pregnancy (TTP) as a measure of couple fecundability, which was defined as the duration between the dates of discontinuing contraceptive procedures and beginning of last menstrual period before pregnancy, and used a structured questionnaire to interview each male worker and his spouse. We conducted the exposure assessment of CS2 using previously air-sampling data. Finally, we analysed the data of TTP using the discrete Cox's proportional hazards model.

Results The pregnancies with the employment of 10 years or more had a lower fecundability density ratio (FDR=0.47; 95% CI: 0.23 to 0.93) and those exposed more than 30 ppm had a lower ratio (FDR=0.58; 95% CI: 0.26 to 1.29) compared to those before the employment. Furthermore, workers exposed more than 30 ppm and their employment of 10 years or more were associated with a decreased fecundability density ratio (FDR=0.42; 95% CI: 0.19 to 0.93).

Conclusions The results showed that the exposure to CS2 had a significantly detrimental effect on male fecundability, especially for those with long duration and high level of CS2 exposure.

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