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Cancer 3
Pesticide exposure in farming and forestry and the risk of uveal melanoma
  1. Thomas Behrens1,
  2. Elsebeth Lynge2,
  3. Ian Cree3,
  4. Jean-Michel Lutz4,
  5. Mikael Eriksson5,
  6. Pascal Guenel6,
  7. Franco Merletti7,
  8. Maria Morales Suarez-Varela8,
  9. Noemia Afonso9,
  10. Aivars Stengrevics10,
  11. Joelle Fevotte11,
  12. Svend Sabroe12,
  13. Agustin Llopis-Gonzalez8,
  14. Giuseppe Gorini13,
  15. Lennart Hardell14,
  16. Andreas Stang15,
  17. Wolfgang Ahrens1
  1. 1Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany
  2. 2University of Copenhagen, Copenhagen, Denmark
  3. 3Institute of Ophthalmology, London, UK
  4. 4University of Zürich, Zürich, Switzerland
  5. 5University Hospital, Lund, Sweden
  6. 6Inserm U1018, Villejuif, France
  7. 7University of Turin, Piemonte, Italy
  8. 8University of Valencia, Valencia, Spain
  9. 9Instituto Portugues de Oncologia, Porto, Portugal
  10. 10Latvia Cancer Registry, Riga, Latvia
  11. 11Institut de Veille Sanitaire, Saint Maurice, France
  12. 12University of Aarhus, Aarhus, Denmark
  13. 13ISPO Cancer Prevention and Research Institute, Florence, Italy
  14. 14University Hospital, Örebro, Sweden
  15. 15University of Halle-Wittenberg, Halle, Germany

Abstract

Objectives Since pesticides are disputed risk factors for uveal melanoma, we studied the association between occupational pesticide exposure and uveal melanoma risk in a case-control study from nine European countries.

Methods Incident cases of uveal melanoma and population as well as hospital controls were included and frequency-matched by country, 5-year age groups and sex. Self-reported exposure was quantified with respect to duration of exposure and pesticide application method. We calculated the exposure intensity level based on application method and use of personal protective equipment. ORs and 95% 95% CIs were estimated by unconditional logistic regression analyses and adjusted for several potential confounders.

Results 293 case and 3198 control subjects were interviewed. We did not identify positive associations with activities in farming or forestry, pesticide application or pesticide mixing. No consistent positive associations were seen with exposure intensity level scores either. The only statistically significantly raised association in this study was for exposure to chemical fertilisers in forestry (OR=8.93; 95% CI 1.73 to 42.13), but this observation was based on only six exposed subjects. Results did not change when we restricted analyses to morphologically verified cases and excluded proxy interviews as well as cancer controls. We did not observe effect modification by sex or eye colour.

Conclusions Risk estimates for pesticide exposures and occupational activities in agriculture and forestry were not increased. The possible risk increase associated with exposure to chemical fertilisers should be reinvestigated in future studies.

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