You are here

Article Text

Article menu

Download PDFPDF

Oral presentations: Day 2: Thursday, September 8, 2011
Lymphatic neoplasms
Lymphoma risk and occupational exposure to pesticides: results of the EPILYMPH study
Free
  1. Michela Pilleri1,
  2. Stefania Dubois1,
  3. Giannina Satta1,
  4. Maristella Lecca1,
  5. Andrea Naitza1,
  6. Mariagrazia Zucca1,
  7. Andrea ‘t Mannetje2,
  8. Nikolaus Becker3,
  9. Silvia De Sanjosé4,
  10. Lenka Foretova5,
  11. Anthony Staines6,
  12. Marc Maynadié7,
  13. Alexandra Nieters3,
  14. Paul Brennan8,
  15. Paolo Boffetta9,
  16. Maria Grazia Ennas1,
  17. Pierluigi Cocco1
  1. 1University of Cagliari, Cagliari, Italy
  2. 2Massey University, Wellington, New Zealand
  3. 3German Cancer Research Center, Heidelberg, Germany
  4. 4Catalan Institute of Oncology, Barcelona, Spain
  5. 5Department of Cancer Epidemiology and Genetics, Brno, Czech Republic
  6. 6Dublin City University, Dublin, Ireland
  7. 7Dijon University Hospital, Dijon, France
  8. 8IARC, Lyon, France
  9. 9Mount Sinai School of Medicine, New York, USA

Abstract

Objectives Several agricultural pesticides have shown a carcinogenic potential in experimental animals.

Methods In 1998–2003, 2337 incident lymphoma cases and 2434 controls participated in the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls. Specific questions for farm workers included type of crop, farm size, pests being treated, type and schedule of pesticide use. We conducted a preliminary analysis of risk of lymphoma and its major subtypes associated with occupational exposure to groups of pesticides. The OR and its 95% CI was calculated with unconditional logistic regression for all lymphomas, and its major subtypes, adjusting by age, gender, and education.

Results Lymphoma risk did not increase among those exposed to inorganic (OR = 1.3, 95% CI 0.9 to 1.7) or organic pesticides (OR = 1.1, 95% CI 0.9 to 1.4). Risk of CLL was significantly increased among those exposed to pesticides (OR = 1.5 95% CI 1.0 to 2.2), and particularly to organophosphates (OR = 2.2, 95% CI 1.1 to 4.4). No other significant associations were observed.

Conclusions Our results confirm previous reports of an increase in risk of specific lymphoma subtypes associated with exposure to specific agrochemicals.

https://doi.org/10.1136/oemed-2011-100382.110

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.