Article Text


Lymphatic neoplasms
Lymphohemopietic neoplasms and dioxin exposure in the Seveso cohort 30 years after the accident (1977–2006)
  1. Angela Cecilia Pesatori1,
  2. Dario Consonni2,
  3. Raquel Carace2,
  4. Raffaella Sindaco2,
  5. Pier Alberto Bertazzi1
  1. 1Università di Milano, Milano, Italy
  2. 2IRCCS Fondazione Ca' Granda, Milano, Italy


Objectives The Seveso accident caused the contamination of a large inhabited area by 2,3,7,8-tetrachlorodibenzodioxin. Three zones with decreasing soil TCDD levels were delimited: A, B and R. Persons ever living in the contaminated zones and in a surrounding non-contaminated area were followed-up to evaluate long-term effects. The main finding of the mortality (1976–2001) and cancer incidence studies (1977–1991) was an increase in lymphohemopoietic cancers in zones A and B. We report preliminary results of the extension of the follow-up to 30 years after the accident for lymphoemopietic cancers.

Methods Incident cases were ascertained through the hospital discharge registration system of the Lombardy region and medical records were reviewed. RR and 95% CI were estimated with Poisson regression techniques controlling for age, gender and calendar period using the non-contaminated area as reference.

Results The incidence of all lymphohemopietic cancers was increased in zone A (6 cases, RR =1.2; 95% CI 0.5 to 2.7) and B (47 cases; RR=1.5; 95% CI 1.1 to 2.0). Non-Hodgkin's lymphomas were modestly increased in zone B, whereas the RR for all leukaemias was 2.0 (95% CI 1.2 to 3.4). 5 cases were lymphatic leukaemia (RR =1.6 95% CI 0.6 to 4.1); 10 myeloid leukaemias showed a RR of 2.1 (95% CI 1.04 to 4.15). All lymphatic leukaemias occurred after 20 years since the accident (RR=4.0; 95% CI 1.4 to 11.6). Myeloid leukaemia did not show a consistent pattern across different categories of time since the accident.

Conclusions The extension of the follow-up confirms an increased risk for lymphatic and haemopoietic cancers, particularly leukemia, in the Seveso population.

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