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Poster-discussion: Cardiovascular disease
Metabolic syndrome and insulin resistance in workers
  1. Wen-Yi Lin1,
  2. Ming-Tsang Wu1,
  3. Ming-Lung Yu3,
  4. Meng-Hsuan Hsieh2,
  5. Chao-Kuan Huang1,
  6. Jeng-Fu Yang2,
  7. Chao-Ling Wang2,
  8. Chung-Feng Huang3,
  9. Chia-I Lin2,
  10. Chia-Yen Dai2,
  11. Hung-Yi Chuang2,
  12. Chi-Kung Ho4
  1. 1Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan
  2. 2Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  3. 3Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan
  4. 4Department of Health, Kaohsiung, Taiwan

Abstract

Objectives The epidemiologic characteristics of metabolic syndrome (MS) and insulin resistance should be an important task for health promotion in workers.

Methods Analysing 3100 data (female: 1125, male: 1975) aged 31.5±12.1 years from completely decoding health surveillance bank. HOMA-IR as insulin sensitivity index was calculated by (Insulin (μU/ml) X Glucose (mmol/l)/22.5). MS was defined on updated NCEP/ATP III criteria modified for Asians.

Results The prevalence of MSin our group was 12%. The 75th percentile of HOMA-IR in non-diabetic cases was 1.88. Diabetes mellitus (DM) was the most significant predictor for MS (10.4 vs 69%, OR=12.0–31.1). In non-diabetic, the major factors were HOMA-IR≥1.88 (4.7 vs 27.6%, OR=6.1–10.1), age, sex (=4.5%,=13.8%, OR=2.5-4.7), hypertension (6.6 vs 35.7%, OR=6.0–10.1), abnormal liver function GPT≥1.3X (8.5 vs 34.7%, OR=4.2–7.8), central obesity (5.2 vs 33.5%, OR=7.1–11.8), body mass index(BMI) (normal (18.5≥BMI<24)=1.9%, overweight (24≥BMI<27)=15%, mild obesity (27≥BMI<30)=34.2%, moderate obesity (30≥BMI<35)=54%, morbid obesity (BMI≥35)=50%, p<0.001), low HDL (6.4 vs 32.3%, OR=5.4–9.0), triglyceride (TG)≥150 mg/dl (3.5 vs 43.8%, OR=16.2–28.1), work-shift (6.1 vs 16.9%, OR=2.4–4.0), work-loading (non=7.4%, heavy=16.1%, OR=1.9–3.0). Logistic regression analysis revealed HOMA-IR, hypertension, TG, BMI, age, GPT≥1.3X, and low HDL were associated with MS in non-diabetics. MS (20.2 vs 66.3%, OR=6.1–10) was the highest predictor of HOMA-IR≥1.88 in non-diabetics. Logistic regression analysis revealed that metabolic syndrome, age≥40 year, GPT≥1.3X, central obesity, BMI≥24, TG≥150 mg/dl, and non-heavy work loading were the major determinants of HOMA-IR≥1.88.

Conclusions High prevalence of MS was noted in workers and it predicts insulin resistance.

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