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Original article: Workplace: The threshold level of urinary cadmium associated with increased urinary excretion of retinol-binding protein and β2-microglobulin: a re-assessment in a large cohort of nickel-cadmium battery workers
  • Agnès Chaumont,
  • Frédéric De Winter,
  • Xavier Dumont,
  • Vincent Haufroid,
  • Alfred Bernard
Occup Environ Med 2011;68:4 257-264 Published Online First: 8 October 2010 doi:10.1136/oem.2009.054122
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  1. Renal effects of cadmium exposure

    • Heikki Savolainen, Prof.
    Dept. of Occup. Safety & Hlth., Tampere, Finland

    Dear Editor,

    I have read with the greatest interest the convincing study on the dose-response of cadmium ions in kidneys (1). Cadmium compounds also harm the proteoglycan metabolism (2), and by using the urinary proteoglycan excretion as an indicator of cadmium effects the threshold would be at 5 microg/g creatinine (3). This agrees very well with the threshold found in the current investigation.

    1 Chaumont A, De Winter F, Dumont X, et al. The threshold level of urinary cadmium associated with increased urinary excretion of retinol- binding protein and beta-2-microglobulin: a reassessment in a large cohort of nickel cadmium battery workers. Occup Environ Med 2011; 68: 257-264

    2 Savolainen H. Cadmium-associated renal disease. Renal Failure 1995; 17: 483-487

    3 Savolainen H. Studies on urinary proteoglycan excretion in occupational cadmium exposure. Pharmacol Toxicol 1994; 75: 113-114

    Conflict of Interest:

    None declared

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    Published 4 April 2011
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  1. Renal effects of cadmium exposure

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