Article Text

PDF
Lung cancer and exposure to quartz and diesel exhaust in Swedish iron ore miners with concurrent exposure to radon
  1. Ingvar A Bergdahl1,
  2. Håkan Jonsson2,
  3. Kåre Eriksson1,
  4. Lena Damber2,
  5. Bengt Järvholm1
  1. 1Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
  2. 2Oncology, Department of Radiation Sciences, Umeå University, Umeå, Sweden
  1. Correspondence to Ingvar A Bergdahl, Occupational Medicine, Umeå University, Umeå SE-901 87, Sweden; ingvar.bergdahl{at}envmed.umu.se

Abstract

Objectives Studies of underground miners have documented an increased risk of lung cancer mainly linked to radon exposure but possibly influenced by other concurrent exposures.

Methods A cohort study was carried out in 8321 iron ore miners with low exposure to radon, employed in 1923–1998 and followed up for lung cancer in 1958–2000. Historical exposures to radon, crystalline silica and diesel exhaust were assessed. Data including exposure to radon, quartz and diesel exhaust from another mine with higher exposure to radon were reanalysed.

Results Miners had increased risk for lung cancer (SIR 1.48 (95% CI 1.22 to 1.78), based on 112 cases during 227 000 person-years). The increased risk could not be explained by exposure to radon or diesel exhaust but was associated with exposure to crystalline silica: SIR 0.96 (0.53 to 1.62), 1.45 (1.10 to 1.87), 1.99 (1.31 to 2.90) and 1.77 (0.92 to 3.10) in groups with exposure to 0, 0–2, 2–5 and >5 mg years/m3, respectively. Reanalysis of data from the other mine indicated that quartz was a possible confounder in the analysis of relationship between radon and lung cancer. In the highest radon exposed group, the point estimate for the RR decreased from 5.65 to 3.90 when adjusting for concurrent exposure to quartz.

Conclusions Crystalline silica, a known carcinogen, probably affects lung cancer risk in iron ore miners. The main implication of the results is for interpretation of the dose–response curve for radon and lung cancer in underground iron ore miners. Since exposure to radon and quartz is often correlated, quartz exposure can be an important confounder.

  • Mining
  • occupations
  • radon
  • quartz
  • vehicle emissions
  • epidemiology
  • cancer
  • diesel fumes
  • dusts
  • radon

Statistics from Altmetric.com

Footnotes

  • Linked article 047449.

  • Funding This study was financially supported by the Swedish Council for Working Life and Social Research, the Swedish Radiation Protection Authority and the Cancer Research Foundation in Northern Sweden.

  • Competing interests None.

  • Ethics approval This study has been approved by the Ethics Committee at Umeå University (ref. 03-040).

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles