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Two cases of birth defects overlapping Stratton-Parker syndrome after multiple pesticide exposure
  1. R Mesnage1,2,
  2. E Clair1,2,
  3. J Spiroux de Vendômois2,
  4. G-E Séralini1,2
  1. 1University of Caen, Risk Pole MRSH CNRS, Biochemistry Laboratory, Caen cedex, France
  2. 2CRIIGEN, Paris, France
  1. Correspondence to G-E Séralini, University of Caen, Risk Pole CNRS, Biochemistry Laboratory EA2608, Esplanade de la Paix, 14032 Caen cedex, France; criigen{at}unicaenfigr

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In January 2009, a farming couple contacted us because two of their three children had been born with congenital malformations. One had a somatotropic deficiency, an imperforate anus and a small atrial septal defect at birth. The other had hypospadias, a micropenis, total deficiency of growth hormone and an imperforate anus. These disorders are rarely encountered together in the same person or family. However, in some cases they have been grouped with other symptoms under Stratton-Parker syndrome, the aetiology of which remains unknown.1 2 Stratton-Parker syndrome symptoms noticeably overlap those found in our cases (table 1). As only males have been affected to date and all cases have occurred sporadically, some authors propose an X-linked recessive inheritance.2 …

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