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Occupational asthma due to 5-aminosalicylic acid
  1. Joaquín Sastre1,2,
  2. Manuela García del Potro1,
  3. Erika Aguado1,
  4. Mar Fernández-Nieto1,2
  1. 1Department of Allergy, Fundación Jiménez Díaz-Capio, Madrid, Spain
  2. 2CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain
  1. Correspondence to Joaquín Sastre, Department of Allergy, Fundación Jiménez Díaz, Av. Reyes Católicos 2, 28040 Madrid, Spain; jsastre{at}fjd.es

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5-Aminosalicylic acid (5-ASA) is an anti-inflammatory drug with a structural resemblance to phenacetin and is widely used to treat inflammatory bowel diseases. 5-ASA is the active constituent of sulphasalazine and sulphapyridine is its transport molecule. Some studies suggest that the serious adverse effects of the drug are in many cases due to sulphapyridine; however, at least in some patients, the adverse effects of sulphasalazine are attributable to 5-ASA itself.1 2 Pharmaceutical development has concentrated on delivering 5-ASA to the mucosa of the small intestine and colon using other inert carriers such as mesalazine. Blood dyscrasias, hepatitis, pancreatitis, pericarditis, pneumonitis and serious skin reactions have been …

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