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Occup Environ Med 66:718-724 doi:10.1136/oem.2008.041798
  • Original article

Rhinitis associated with pesticide exposure among commercial pesticide applicators in the Agricultural Health Study

  1. R E Slager1,
  2. J A Poole2,
  3. T D LeVan2,3,
  4. D P Sandler4,
  5. M C R Alavanja5,
  6. J A Hoppin4
  1. 1
    Center for Human Genomics, Department of Pediatrics, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA
  2. 2
    Pulmonary, Critical Care, Sleep, and Allergy Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
  3. 3
    Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA
  4. 4
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
  5. 5
    Occupational Epidemiology Branch, NCI, NIH, DHHS, Rockville, Maryland, USA
  1. Correspondence to Dr Jane A Hoppin, Epidemiology Branch, NIEHS, PO Box 12233, MD A3-05, Research Triangle Park, NC 27709, USA; hoppin1{at}niehs.nih.gov
  • Accepted 7 February 2009
  • Published Online First 15 March 2009

Abstract

Objectives: Rhinitis is common, but the risk factors are not well described. To investigate the association between current rhinitis and pesticide use, we used data from 2245 Iowa commercial pesticide applicators in the Agricultural Health Study.

Methods: Using logistic regression models adjusted for age, education and growing up on a farm, we evaluated the association between current rhinitis and 34 pesticides used in the past year.

Results: 74% of commercial pesticide applicators reported at least one episode of rhinitis in the past year (current rhinitis). Five pesticides used in the past year were significantly positively associated with current rhinitis: the herbicides 2,4-D, glyphosate and petroleum oil, the insecticide diazinon and the fungicide benomyl. The association for 2,4-D and glyphosate was limited to individuals who used both in the past year (OR 1.42, 95% CI 1.14 to 1.77). Both petroleum oil and diazinon showed consistent evidence of an association with rhinitis, based on both current use and exposure–response models. We saw no evidence of confounding by common agricultural rhinitis triggers such as handling grain or hay.

Conclusions: Exposure to pesticides may increase the risk of rhinitis.

Footnotes

  • See Commentary, p 715

  • Funding This work was supported by intramural research funds from the National Cancer Institute and the National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services. RES was supported by a National Institute of Alcohol Abuse and Alcoholism R01 to principal investigator Joseph H Sisson, MD at the University of Nebraska Medical Center.

  • Competing interests None.

  • The institutional review boards of the National Institutes of Health (Bethesda, Maryland) and its contractors approved the Agricultural Health Study.

  • Provenance and peer review Not commissioned; externally peer reviewed.