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Occup Environ Med 2008;65:437 doi:10.1136/oem.2007.037523
  • Editorial

Organochlorine compounds and thyroid dysfunction in children: is there a link with neurotoxicity?

  1. Leda Chatzi
  1. Dr Leda Chatzi, Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, Heraklion, 71003, Crete, Greece; lchatzi{at}med.uoc.gr

    Recent epidemiological and experimental studies have suggested that persistent organochlorine compounds (OCs) such as polychlorinated biphenyls (PCBs) and dioxins may alter thyroid hormone levels in animals and humans. As neurological development occurs in discrete developmental windows, even transient disorders in thyroid hormone availability can have profound effects on brain development.1 Most studies have focused on the effects of prenatal exposure, but little evidence exists concerning the effects of exposure to OCs during childhood.

    Further research on the latter is reported in a paper by Álvarez-Pedrerol et al in this issue (see page 452).2 Exposure to certain OCs such as dichlorodiphenyl trichloroethane (p,p′-DDT), β-hexachlorocylcohexane (β-HCH) and polychlorinated biphenyls (congeners PCB-138, PCB-153 and PCB-118) …

    [Full text of this article]

    Relevant Article

    • Original article: Effects of PCBs, p,p′-DDT, p,p′-DDE, HCB and β-HCH on thyroid function in preschool children
      • M Álvarez-Pedrerol,
      • N Ribas-Fitó,
      • M Torrent,
      • D Carrizo,
      • J O Grimalt,
      • J Sunyer
      Occup Environ Med 2008;65:452-457 Published Online First: 12 October 2007 doi:10.1136/oem.2007.032763

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