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Neuropsychiatric symptoms in past users of sheep dip and other pesticides
  1. Christine Solomon1,
  2. Jason Poole1,
  3. Keith T Palmer1,
  4. Robert Peveler2,
  5. David Coggon1
  1. 1MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
  2. 2Community Clinical Sciences, University of Southampton, Southampton, UK
  1. Correspondence to:
 Professor D Coggon
 MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton SO16 6YD, UK; dnc{at}mrc.soton.ac.uk

Abstract

Objectives: To explore the prevalence and pattern of neuropsychiatric symptoms in past users of sheep dip and other pesticides.

Methods: From a postal survey of men born between 1933 and 1977 and resident in three rural areas of England and Wales (response rate 31%), data were obtained on lifetime history of work with pesticides, neurological symptoms in the past month, current mental health and tendency to be troubled by non-neurological somatic symptoms (summarised as a somatising tendency score). Risk factors for current neuropsychiatric symptoms were assessed by modified Cox regression.

Results: Data were available for 9844 men, including 1913 who had worked with sheep dip, 832 with other insecticides but not sheep dip and 990 with other pesticides but never with sheep dip or insecticides. Neurological symptoms were consistently 20–60% more common in past users of sheep dip than in men who had never worked with pesticides, but their prevalence was also higher in men who had worked only with pesticides other than sheep dip or insecticides. They clustered strongly within individuals, but this clustering was not specific to men who had worked with sheep dip. Reporting of three or more neurological symptoms was associated with somatising tendency (prevalence ratio (PR) 15.0, 95% CI 11.4 to 19.5, for the highest vs the lowest category of somatisation) and was more common in users of sheep dip (PR 1.3, 95% CI 1.0 to 1.6), other insecticides (PR 1.4, 95% CI 1.0 to 1.8) and other pesticides (PR 1.3, 95% CI 1.0 to 1.7) than in non-users. Among users of sheep dip, prevalence was higher in men who had dipped most often, but not in those who had worked with sheep dip concentrate. Past use of pesticides was not associated with current anxiety or depression.

Conclusion: Neurological symptoms are more common in men who have worked with sheep dip, but the association is not specific to sheep dip or insecticides. A toxic cause for the excess cannot be ruled out, but several features of our observations suggest that psychological mechanisms have a role.

  • COPIND, chronic organophosphate-induced neuropsychiatric disorder

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Footnotes

  • Published Online First 9 November 2006

  • Competing interests: None declared.

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