Statistics from Altmetric.com
202 FARMING EXPOSURE AND EARLY-ONSET PROSTATE CANCER
To examine the hypotheses that early-onset prostate cancer are associated with age specific general farming exposures and exposure to triazine herbicides.
A population-based case-control study of prostate cancer recruited all early-onset cases (diagnosed under age 60; n = 1198) and 10% of late-onset cases (diagnosed age 60–79; n = 385) from Minnesota and Wisconsin state cancer registries. Controls were selected from state drivers’ license/ID records and frequency matched by age. In-person interviews ascertained history of living or working on a farm or ranch, specific pesticide exposures, demographic information, lifestyle, medical history, and family history of cancer. Total fat intake came from a self-administered food frequency questionnaire. A cumulative triazine exposure index was based on the number of applications per year and years of application of all triazine chemicals. General farming exposures from living or working on a farm were classified as exposure only as a child, as a child and an adult, and only as an adult. Odds ratios (OR) and 95% confidence intervals (CI) for early and late onset prostate cancer were estimated using a logistic regression controlling for potential confounders.
Compared to men who reported no farming exposure, the risk of early-onset prostate cancer was not associated with living or working on a farm only as a child (OR 0.97, 95% CI 0.78 to 1.19) or as a child and an adult (0.86, 95% CI 0.72 to 1.16), but may be lower when exposed only as an adult (OR 0.61, 95% CI 0.37 to 1.02). Risk of later onset prostate cancer was associated with childhood-only exposure (OR 1.43, 95% CI 1.02 to 2.00), but not exposure as an adult and child (OR 1.04, 95% CI 0.72 to 1.50) or only as an adult (OR 0.61, 95% CI 0.24 to 1.57). Compared to men with no triazine exposure, the risk of early-onset prostate …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.