Occup Environ Med 63:451-455 doi:10.1136/oem.2006.026716
  • Original article

A 12 year prospective study of circulatory disease among Danish shift workers

  1. F Tüchsen,
  2. H Hannerz,
  3. H Burr
  1. National Institute of Occupational Health, Copenhagen, Denmark
  1. Correspondence to:
 Dr F Tüchsen
 National Institute of Occupational Health, Lersø Parkallé 105, DK-4000 Copenhagen Ø, Denmark; ft{at}
  • Accepted 24 March 2006
  • Published Online First 30 May 2006


Background: Previous studies of the risk of heart disease after shift work reached different estimates and review authors disagree about the validity of some of the studies. A cross sectional study showed that shift workers had a higher prevalence of nearly every unfavourable work environment factor investigated. Conflicts at work and low decision latitude were more frequent among shift workers, and all-day walking or standing work and part-time jobs were more often found among female shift workers.

Objectives: To estimate the risk of circulatory disease in a prospective follow up of a representative sample of gainfully employed Danes, considering known or suspected confounding factors.

Methods: A cohort of 5517 people who were gainfully employed in 1990 were followed up for all hospital treatments due to circulatory diseases (390–458, ICD-8; I00–I99, ICD-10) from 1991 to 2002 inclusive. A log linear Poisson regression model was applied to control confounding factors and calculate the relative risk for 927 men and women working nights, evenings, or other non-day shifts compared to 4579 day workers.

Results: Non-day workers compared to day workers had a relative risk (RR) for all circulatory diseases of 1.31 (95% CI 1.06–1.63). Without control for BMI and smoking, the RR estimate was 1.33 (95% CI 1.07–1.65). For a subgroup of workers with at least three years’ seniority, the RR was 1.40 (95% CI 1.09–1.81). The population based aetiological fraction of shift work was estimated to 5%.

Conclusion: This study adds to a growing body of evidence suggesting that shift work carries an excess risk of circulatory diseases.


  • Published Online First 30 May 2006

  • Competing interests: none declared

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