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The role of occupation in the development of chronic obstructive pulmonary disease (COPD)
  1. M Meldrum,
  2. R Rawbone,
  3. A D Curran,
  4. D Fishwick
  1. Health and Safety Laboratory and University of Sheffield, UK
  1. Correspondence to:
 Dr D Fishwick
 Health and Safety Laboratory and University of Sheffield, Harpur Hill, Buxton SK17 9JN, UK; david.fishwickhsl.gov.uk

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A discussion of current issues

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide.1 In the UK, COPD is given as the cause of death on about 30 000 death certificates annually.2 This represents 5.1% of all deaths. The prevalence of COPD is difficult to determine because the condition does not usually manifest until mid-life, when it is already moderately advanced. In England and Wales, it is estimated that there are currently 900 000 diagnosed cases, and allowing for under-diagnosis the true prevalence is estimated to be 1.5 million.3 The total annual cost to the National Health Service for the treatment of COPD is thought to be £491 652 000 in direct costs, and £982 000 000 including indirect costs, causing 21.9 million working days to be lost in 1994–95 as a result of this condition.

A recent clinical study from the UK noted that in a random sample of COPD patients, 44% were below retirement age, and 24% reported that they were completely prevented from working by their disease.4 A further 9% were limited in their ability to work, and patient carers also missed time from work. Established disease clearly interferes with work capability.

Cigarette smoking is undoubtedly the main cause of COPD in the population, but the link between harmful workplace exposures and COPD has been debated for many decades. Indeed, awareness of a link between work in dusty trades and chronic bronchitis (termed industrial bronchitis5) can be traced back to the 19th century. In 1984, the US Surgeon General’s report concluded that the only accepted cause of COPD was tobacco smoke; occupational exposures were characterised as putative rather than established causes.6 Since 1993 British coalminers with chronic bronchitis and emphysema (COPD) have been eligible for compensation if they have worked underground for at least 20 years.7 This would appear to acknowledge coalmine dust as a cause of COPD. This conclusion was subsequently endorsed following deliberations by the High Court in 1999, although not without controversy. In toxicological terms, there is nothing particularly harmful about coalmine dust compared to other workplace dusts, the key difference perhaps relating simply to generally higher and more prolonged exposures compared to most “above-ground” exposures. Certainly there is biological plausibility to the view that daily inhalation exposures over many years to high enough concentrations of dusts and irritants could cause lung damage eventually predisposing to COPD.

While the evidence for occupational exposures and asthma is more substantial, there is growing evidence from large population based studies in a number of countries suggesting that a sizeable proportion of the cases of COPD in society may be attributable to workplace exposures to dusts, noxious gases/vapours, and fumes (DGVFs), the so-called “occupational COPD effect”. The excess of COPD found in a DGVF exposed group (after correcting for smoking and other confounders) is calculated as the attributable risk due to these exposures. If the proportion of DGVF exposed workers in the general population is known or can be estimated, the population attributable risk (PAR) can be determined. For example, in one recent study of 9823 subjects aged 30–75 years randomly sampled from the US population, 693 (7.1%) were identified as having COPD.8 Based on an analysis of the industries and occupations from which all 9823 subjects were drawn, and taking into account confounders such as smoking, age, sex, and socioeconomic status, the authors estimated that the population burden of COPD due to occupational exposure to DGVFs was 19.2%. In non-smokers, the proportion of work related COPD was estimated at 31%.

The American Thoracic Society (ATS)9 recently produced a consensus statement based on an evaluation of a number of large scale general population studies, and calculated PARs for both COPD and asthma. From these studies it was calculated that the PAR% for both asthma and COPD was about 15%. None of the supporting studies assessed by the American Thoracic Society were conducted in the UK (as no appropriate UK studies exist).

It should be noted that in some of the large scale general population studies assessed by the American Thoracic Society, the original aim was to determine the overall impact of workplace exposures on the population burden of COPD, and not necessarily to identify workplace specific causes. However, in certain studies, information was sought on the specific substances and occupations associated with increased prevalences of COPD. Occupations linked to increased prevalences of COPD include construction,8,10,11 leather, rubber, plastics manufacturing,8 plastics and rubber workers,10 textiles,8,12 food products,8,10,13 spray painters,10 and welders.10 Specific substances linked to higher prevalences of COPD include quartz,11,14 welding fumes,15 wood dust,15 sawdust,12 asbestos,11,14 and solvents.11

Further data are available from the European Community Respiratory Health Survey,16 using pooled data from 14 industrialised countries. Exposure to vapours, gases, dust, or fumes was associated with an increased prevalence ratio of chronic bronchitis in smokers. Individuals associated with this increased risk were agricultural, textile, paper, wood, chemical, and food processing workers. Again, data from the New Zealand component of the ECRHS17 also noted an association with self-reported exposure to dust, vapours, fumes, and gases and both chronic bronchitis and airways obstruction. This study was limited to subjects under 45 years old, and identified bakers and spray painters at an increased risk.

Similarly, a large Norwegian study10 identified exposures to quartz, metal gases, aluminium production and processing, and welding as being significantly associated with airways obstruction after adjusting for sex, age, and smoking. In addition, exposure to quartz and asbestos was significantly associated with airways obstruction in those over 50 years old. This study also noted an overall effect of significant harmful exposure in the workplace (odds ratio 3.6, 95% confidence interval 1.3 to 9.9) on the development of obstructive airways disease in comparison to non-exposed individuals. A study based in Northern Italy14 confirmed these findings and documented a causal association between occupational exposure and chronic obstructive pulmonary disease.

While cigarette smoking and occupational exposures appear to account in combination for the major proportion of the population attributable risk of COPD, other influences are potentially important. The understanding of genetic susceptibility to this condition is still in its relative infancy, but certain data do suggest genetics influences may be important,18 when considering both established disease and accelerated annual decline in FEV1. Furthermore, interactions have been noted between α1 anti-trypsin deficiency and environmental exposures in the development of COPD.19

Despite the above level of evidence, very little population data exist relating to the situation in the UK. One reason for this may be that, unlike occupational asthma, COPD tends not to be reported via national occupational health surveillance schemes such as SWORD20 (Surveillance of Work-related Occupational Respiratory Disease). This clearly reflects the clinical difficulties in attributing workplace causation for an individual patient with COPD, particularly as the majority have also smoked cigarettes. This is further compounded by the fact that COPD develops slowly, so that current cases of potential work related COPD are likely to reflect workplace exposures over the previous few decades.

As a result of these issues being recently highlighted, the Health and Safety Executive is now considering a more widely based strategy to reduce the impact of occupational respiratory disease in addition to its publicised occupational asthma strategy21 for which a programme of work is underway.22 There now appears to be a reasonable evidence base to support harmful occupational exposures as an independent cause of COPD. As such, regulators and occupational health professionals now need to consider what actions will be required to reduce relevant exposures. Indeed, reducing harmful workplace exposures may be practically easier in certain circumstances than smoking cessation.

Urgent research priorities include establishing the baseline domestic situation, as there is a lack of any relevant UK population data, while also concentrating on achieving and maintaining good practical workplace interventions to reduce harmful dust exposure. The term “nuisance dust”, used to classify certain low toxicity dusts without a specific workplace occupational exposure limit, is misleading at best, and potentially gives false reassurance to workers and employers. This term should be revisited. In addition, the UK Control of Substances Hazardous to Health (COSHH) Regulations state that any dust not otherwise classified as harmful should be regarded as hazardous to health at airborne concentrations of 4 and 10 mg/m3 (respirable and inhalable fractions respectively). These levels almost certainly need to be lowered. The financial burden of COPD alone to our country should supply incentive to all those in positions of responsibility, irrespective of the personal and medical costs. Even if one assumes a relatively conservative estimate, 10% of the current approximate costs of the medical treatment of COPD in the UK equates to £100 million, and this does not take into account productivity losses due to working days lost.

Answers to multiple choice questions on Design of exposure questionnaires for epidemiological studies by M J Nieuwenhuijsen, on pages 272–280

  1. c

  2. a, b, d

  3. b

  4. a

  5. a, and perhaps b

  6. a, b, d, and often c

  7. b

A discussion of current issues

REFERENCES

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