O20.1 OCCUPATIONAL RISKS IN THE POPULATION BASED CASE–CONTROL STUDY, GENETIC EPIDEMIOLOGY OF LUNG CANCER AND SMOKING (GELCS)

D. Consonni¹, P. A. Bertazzi¹, A. C. Pesatori¹, A. Colombi¹, E. Bramati¹, M. Corno¹, M. Rubagotti¹, B. Marinelli¹, B. Albetti¹, M. Bonzini¹, S. Giacomini¹, C. Mensi¹, N. Caporaso², M. T. Landi².¹Department of Occupational Health, Istituti Clinici di Perfezionamento and University of Milan, Milan, Italy; ²Division of Cancer Epidemiology and Genetics, NCI/NIH/DHHS, Bethesda, MD, USA

Introduction: A population based case–control study (Genetic Epidemiology of Lung Cancer and Smoking; GELCS) is being conducted in Lombardy, northern Italy. The research is sponsored by the NCI in the USA, and has the participation of 13 large hospitals. The aim is to enrol 2000 incident cases and 2000 randomly selected population controls (frequency matched to cases by area, sex, amd age quinquennia) in the study period April 2002 to early 2005. Pathological biospecimens are collected from cases, and a blood sample (or a buccal rinse) from all the participants; through a computer assisted personal interview and a self administered questionnaire, detailed information is recorded on numerous risk factors, including smoking and occupational history (jobs held for 6+ months). We performed preliminary analyses of occupational lung cancer risks on a sample of 721 subjects (389 cases and 332 controls, 82% and 77% males, respectively) selected for proteomics analyses.

Methods: Jobs were first coded according to international classifications of industry and occupations (ISIC 71, ISCO 68), and then, following a standardised method, classified as known (List A) or suspected (List B) lung carcinogens where applicable. We used unconditional logistic regression to compute odds ratios (ORs) and 95% confidence intervals (95% CI) adjusted for area, age, cigarette smoking (pack years, as a continuous variable, and its square), …