Table 4
Relation between urinary cotinine, NAT2 phenotype, mild skin aberrations, and ln transformed exposure measures and Sunday and weekday urinary mutagenicity (rev/g creatinine) of rubber manufacturing workers, excluding technical engineers* (n=91)
| Sunday urinary mutagenicity | Weekday urinary mutagenicity | |||
|---|---|---|---|---|
| β (SE)† | p value | β (SE)† | p value | |
| *Technical engineers were not included in the analysis due to missing ambient mutagenic exposure estimates. | ||||
| †β coefficient and standard error of estimate. | ||||
| ‡Relative to fast acetylation phenotype. | ||||
| §Minor dermatitis and/or traumata of the skin. | ||||
| ¶Effect estimates presented for TSPM mutagenicity are from the univariate analysis; TSPM mutagenicity was not included in the multivariate analysis to limit the degrees of freedom used in the analysis and because of the moderate correlation between TSPM and surface mutagenicity (r=0.49). | ||||
| Intercept | 8.02 (0.51) | <0.0001 | 8.09 (0.42) | <0.0001 |
| Urinary cotinine (μg/g creatinine) | 0.22 (0.05) | <0.0001 | 0.24 (0.04) | <0.0001 |
| Slow acetylation (NAT2)‡ | 0.11 (0.29) | 0.70 | 0.54 (0.23) | 0.02 |
| Mild skin aberrations§ | 0.42 (0.30) | 0.15 | 0.37 (0.24) | 0.12 |
| Inhalable particulate (mg/m3) | 0.40 (0.22) | 0.07 | 0.42 (0.18) | 0.02 |
| Surface mutagenicity (rev/cm2) | 0.22 (0.12) | 0.07 | 0.28 (0.10) | 0.005 |
| TSPM mutagenicity (rev/m3)¶ | 0.07 (0.13) | 0.61 | 0.11 (0.14) | 0.44 |
