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Occup Environ Med 2002;59:734-738 doi:10.1136/oem.59.11.734
  • Original article

Lead induced increase of blood pressure in female lead workers

  1. K Nomiyama1,
  2. H Nomiyama1,
  3. S-J Liu2,
  4. Y-X Tao3,
  5. T Nomiyama4,
  6. K Omae5
  1. 1Department of Occupational and Environmental Health, Jichi Medical School, Tochigi-Ken 329-0498, Japan
  2. 2Beijing Medical University School of Public Health, Beijing 100083, China
  3. 3Beijing City Institute for Occupational Health, Beijing 100020, China
  4. 4Division of Environmental Medicine, Department of Preventive Medicine, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan
  5. 5Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo 160–8582, Japan
  1. Correspondence to:
 Dr K Nomiyama, Midori 3-12-1, Minamikawachi-Machi, Tochigi-Ken 329-0433, Japan;
 nomiyama{at}jichi.ac.jp
  • Accepted 10 April 2002

Abstract

Aims: Although lead exposure has, in the absence of mathematical modelling, been believed to elevate blood pressure in females, it is necessary to clarify the relation between lead and blood pressure by eliminating confounding factors in the analysis.

Methods: Blood lead was measured in 193 female workers, including 123 lead exposed workers. Possible confounding factors were controlled by multiple regression analyses.

Results and Conclusion: Blood lead above 40 μg/dl was found to be the most potent factor for elevating systolic/diastolic blood pressure. Aging, urine protein, and plasma triglyceride also contributed to systolic/diastolic/pulse pressure increase, but hypertensive heredity did not. Data suggested that lead induced changes in lipoprotein metabolism may play an important role in the lead induced blood pressure increase in female workers.

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