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Occup Environ Med 59:723-728 doi:10.1136/oem.59.11.723
  • Original article

Exposure-response analysis and risk assessment for silica and silicosis mortality in a pooled analysis of six cohorts

Table 3

Results of nested case-control analysis, relative risk models

Model χ2, 1 df RR* (95% CI)
Cases and controls were matched for age, race, sex, date of birth, and study.
*Rate ratio for increase of one unit of each exposure measure.
Continuous exposure measures
Cumulative exposure (mg/m3-y) 30.9 1.04 (1.03 to 1.06)
Average exposure rate over working period (mg/m3) 19.9 2.77 (1.80 to 4.26)
Duration of exposure (y) 27.2 1.04 (1.02 to 1.06)
Log transformed cumulative exposure (log mg/m3-days) 73.2 2.08 (1.71 to 2.53)
Log transformed cumulative exposure (log mg/m 3 -days)
By study
    1. US diatomaceous earth workers 2.08 (1.23 to 3.52)
    2. Finnish granite workers 2.76 (1.37 to 5.57)
    3. US granite workers 1.76 (1.30 to 2.38)
    4. US industrial sand workers 1.63 (1.03 to 2.57)
    5. US gold miners 3.57 (1.90 to 6.69)
    6. Australian gold miners 2.31 (1.34 to 3.97)
By age of death (of the cases)
    <65 years 2.70 (1.90 to 3.84)
    ≥65 years 1.81 (1.44 to 2.29)

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