Regression coefficients of the adjusted associations between serum concentrations of thyroid stimulating hormone (TSH), thyroxine (total T4 and free T4), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and glutamyl transpeptidase (GGT), and serum concentrations of HCB and PCB in quartiles (model 1) and as continuous variable (model 2)
| Variables | Coefficient (SE) | |||||
|---|---|---|---|---|---|---|
| ln (TSH) | Total T4 | Free T4 | ln (AST) | ln (ALT) | ln (GGT) | |
| Reference4-151 | 0.36 (0.07) | 8.56 (0.34) | 1.34 (0.04) | 2.89 (0.05) | 2.32 (0.09) | 2.43 (0.12) |
| Model 1: | ||||||
| Quartiles HCB( ng/ml): | ||||||
| 9.8–12.5 | −0.02 (0.08) | −0.80 (0.37)4-150 | −0.08 (0.04) | 0.02 (0.06) | −0.08 (0.10) | −0.03 (0.13) |
| 12.5–16.5 | −0.01 (0.09) | −0.85 (0.41)4-150 | −0.06 (0.05) | 0.04 (0.07) | 0.02 (0.11) | 0.21 (0.14) |
| 16.5 | −0.11 (0.07) | −1.16 (0.38)4-150 | −0.04 (0.05) | 0.00 (0.06) | 0.01 (0.11) | 0.22 (0.13)4-150 |
| Quartiles PCBs (ng/ml): | ||||||
| 1.3–2.6 | −0.02 (0.07) | −0.66 (0.31)4-150 | −0.01 (0.04) | 0.03 (0.05) | 0.04 (0.08) | 0.18 (0.11) |
| 2.6–5.0 | −0.07 (0.08) | −0.47 (0.33) | −0.01 (0.04) | 0.01 (0.05) | 0.05 (0.09) | 0.15 (0.11) |
| >5.0 | −0.01 (0.09) | −0.07 (0.33) | 0.02 (0.04) | 0.05 (0.05) | 0.05 (0.09) | 0.30 (0.11)4-150 |
| Model 2: | ||||||
| Ln (HCB) ng/ml4-152 | −0.02 (0.03) | −0.32 (0.11)4-150 | −0.01 (0.01) | 0.001 (0.02) | 0.02 (0.03) | 0.10 (0.04)4-150 |
| Ln (PCB) ng/ml4-152 | 0.005 (0.03) | −0.01 (0.09) | 0.007 (0.01) | 0.004 (0.01) | 0.002 (0.02) | 0.05 (0.03) |
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↵4-150 p<0.05.
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↵4-151 Reference category (SE): mean concentrations for women of 46 years old and 24 kg/m2 of body mass index, without alcohol consumption, who had never been working in the electrochemical factory and with HCB and PCB serum concentrations lower than 9.8 ng/ml and 1.3 ng/ml, respectively.
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↵4-152 Adjusted change for each unit change in ln HCB or ln PCB, adjusted by sex, age, body mass index, and alcohol consumption. The model includes both HCB and PCB concentrations as continuous variable.
