Sorahan, Tom; Hamilton, Linda; Jackson, John R

Table 9

Relative risk of bladder cancer (all notifications of malignant neoplasms^8-151) by potential exposure to various chemicals: employment histories are unlagged

Variable with levels	n	RR (95% CI) separate analysis^8-152		RR (95% CI) simultaneous analysis^8-153
Cumulative exposure to MBT (mg.μ^-3y):
None	21	1.0		1.0
0.01–21.24	5	2.96^8-150	(1.11 to 7.86)	2.24	(0.76 to 6.60)
21.25–63.74	3	2.50	(0.74 to 8.38)	1.46	(0.38 to 5.63)
⩾63.75	1	1.72	(0.23 to 12.82)	1.21	(0.15 to 9.54)
p Value for trend^8-154		p=0.06		p=0.48
Duration of employment in PBN department (y):
None	25	1.0		1.0
1–4	1	1.26	(0.17 to 9.32)	0.58	(0.06 to 5.46)
⩾5	4	7.48^8-160	(2.60 to 21.52)	4.35^8-150	(1.30 to 14.57)
p Value for trend^8-154		p<0.001		p=0.03
Duration of employment in aniline department (y):
None	23	1.0		1.0
1–4	2	0.85	(0.20 to 3.61)	0.61	(0.14 to 2.76)
⩾5	5	2.20	(0.84 to 5.79)	1.50	(0.52 to 4.35)
p Value for trend^8-154		p=0.17		p>0.50
Duration of employment in o-toluidine department (y):
None	27	1.0		1.0
1–4	2	6.73^8-150	(1.59 to 28.41)	5.18^8-150	(1.04 to 25.80)
⩾5	1	7.65^8-150	(1.03 to 56.87)	2.73	(0.29 to 25.45)
p Value for trend^8-154		p=0.002		p=0.31

↵8-150 p<0.05;
↵8-160 p<0.01;
8-165 p<0.001.
↵8-151 See table 3, second column.
↵8-152 Column summarises four analyses, only adjusting for age.
↵8-153 Column summarises a single analysis in which the four chemical exposure variables are analysed simultaneously with age.
↵8-154 See text.

A further cohort study of workers employed at a factory manufacturing chemicals for the rubber industry, with special reference to the chemicals 2-mercaptobenzothiazole (MBT), aniline, phenyl-β-naphthylamine and o-toluidine

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