Table 3
Description of published substance specific studies which examined workers in the mortality surveillance study
| Purpose of study, definition of study group, and reference | Workers under Surveillance | Disease site(s) of interest (ICD-8)3-150 |
Author(s) finding of cause |
Study result SMR (95% CI) [obs] | Surveillance results (⩾20 y induction-latency) SMR (95% CI) [obs or exp] | ||
| 261 Workers employed at the Nitro plant with potential exposure to 4-aminobiphenyl15 | 52 | Bladder cancer (188,189.9) | Yes | 42/261 Workers developed bladder cancer | 1.6 (0.0 to 8.8) [1] | ||
| 54 Workers employed at the Queeny plant with potential exposure to 4-aminobiphenyl15 | 11 | Bladder cancer (188,189.9) | Yes | 10/54 Workers developed bladder cancer | 1.9 (0.2 to 7.0) [2] | ||
| 2490 Male hourly workers at the Indian Orchard plant working 1 year between 1949–66 with follow up to the end of 197619 | 224 | Genitourinary tract cancers (185–189) | Yes | 1.7 (1.1 to 2.5) [26] | 0.3 (0.0 to 0.8) [4] | ||
| Cancer of digestive organs and peritoneum (150–159) | Yes | 1.3 (0.9 to 1.7) [44] | 1.2 (0.8 to 1.8) [26] | ||||
| 2731 Workers employed at the Indian Orchard plant with potential exposure to formaldehyde22 | 218 | Lung cancer (162) | No | 1.1 (1.0 to 1.3) For all plants in study | 0.6 (0.4 to 0.9) [23] | ||
| 452 Workers with exposure to dioxins from 1948–69 at the Nitro plant24 | 36 | Lung cancer (162) | Yes | 1.4 (0.8 to 0.4) [15] | 0.6 (0.2 to 1.3) [6] | ||
| Soft tissue sarcoma (171) | Yes | 15.2 (1.9 to 55.6) [2] | 0.0 (0.0 to 121.0) [0.16 exp] | ||||
| 96 Workers with exposure to dioxins from 1948–69 at the Krummrich plant24 | 7 | Lung cancer (162) | Yes | 2.4 (0.5 to 7.0) [3] | 0.9 (0.5 to 1.4) [18] | ||
| Soft tissue sarcoma (171) | Yes | 0.0 [0] | 0.0 (0.0 to 14.9) | ||||
| 754 Workers employed at the Nitro plant during 1949 with follow up to the end of 198727 | 128 | Soft tissue sarcoma (171,173.9) | Yes | 6.7 (1.4 to 19.4) [3] | 0.0 (0.0 to 121.0) [0.16 exp] | ||
| Bladder cancer (188,189.9) | Yes | 6.8 (3.9 to 11.1) [16] | 1.6 (0.0 to 8.8) [1] | ||||
| 666 Production workers at the Krummrich plant 1940–77 with follow up to the end of 199129 | 406 | Leukaemia (204–207) | Yes | 1.4 (0.8 to 2.2) [19] | 2.4 (0.7 to 6.2) [4] | ||
| Multiple myeloma (203) | Yes | 1.3 (0.5 to 2.5) [8] | 1.2 (0.0 to 6.8) [1] | ||||
| 2039 Workers employed at the Chocolate Bayou plant 1962–1983 with follow up to the end of 198930 | 1468 | Lung cancer (162) | No | 0.2 (0.0 to 1.1) [1] | 0.5 (0.1 to 1.3) [4] | ||
| Brain cancer (191,192) | No | 1.2 (0.2 to 8.3) [1] | 1.8 (0.0 to 9.9) [1] | ||||
| Prostate cancer (185) | No | 2.1 (0.3 to 14.9) [1] | 0.0 (0.0 to 4.2) [0.86 exp] | ||||
| 7372 Workers employed at the Decatur plant 1952–83 with follow up to the end of 198930 | 5308 | Lung cancer (162) | No | 0.6 (0.4 to 0.9) [2] | 0.6 (0.3 to 1.0) [13] | ||
| Brain cancer (191,192) | No | 0.8 (0.3 to 2.1) [4] | 1.8 (0.0 to 9.9) [1] | ||||
| Prostate cancer (185) | No | 0.9 (0.3 to 2.5) [4] | 1.0 (0.2 to 3.0) [3] | ||||
| 2368 Workers employed at the Port Plastics plant 1959–83 with follow up to the end of 198930 | 1705 | Lung cancer (162) | No | 0.8 (0.4 to 1.5) [8] | 0.9 (0.4 to 1.8) [7] | ||
| Brain cancer (191,192) | No | 0.0 (0.0 to 2.7) [0] | 1.5 (0.0 to 8.3) [1] | ||||
| Prostate cancer (185) | No | 0.0 (0.0 to 4.0) [0] | 1.1 (0.0 to 5.9) [1] | ||||
| 600 White male hourly 2-mercaptobenzothizole workers at the Nitro plant working between 1955–77 with follow up to the end of 197631 | 390 | Bladder cancer (188,189.9) | Yes | 6.3 (3.6 to 10.3) [16] | 1.6 (0.0 to 8.8) [1] | ||
| 185 Workers employed at the Indian Orchard plant with potential exposure to vinyl chloride32 | 98 | Liver cancer (155,156) | Yes | 3.5 (2.8 to 4.5) For all plants in study: 1 death at plant |
0.0 (0.0 to 1.6) [2.33 exp] | ||
| Brain cancer (191–192) | Possibly | 1.4 (1.0 to 2.0) For all plants in study: no deaths at plant |
0.4 (0.0 to 2.3) [1] | ||||
| Soft tissue sarcoma (171) | Yes | 2.7 (1.4 to 4.7) For all plants in study: no deaths at plant |
0.0 (0.0 to 7.6) [0.48 exp] | ||||
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↵3-150 Hypothesis tested in study or high rate of disease reported.
