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Cutaneous absorption of trivalent chromium: tissue levels and treatment by exchange transfusion
  1. W F Kelly1,
  2. P Ackrill1,
  3. J P Day2,
  4. Maureen O'Hara2,
  5. C T Tye2,
  6. I Burton3,
  7. C Orton4,
  8. M Harris5
  1. 1Department of Nephrology, University Hospital of South Manchester (Withington Hospital), UK
  2. 2Department of Chemistry, University of Manchester, Manchester, UK
  3. 3The Department of Haematology, University Hospital of South Manchester (Withington Hospital), UK
  4. 4The Department of Plastic Surgery, University Hospital of South Manchester (Withington Hospital), UK
  5. 5The Department of Histopathology, University Hospital of South Manchester (Withington Hospital), UK

    Abstract

    ABSTRACT A man was accidentally immersed in hot acidic trivalent chromium sulphate solution but none was swallowed. The clinical course was dominated by burns, intravascular haemolysis, and acute renal failure. Blood concentrations of chromium were measured during treatment and tissue concentrations were measured at death. Exchange transfusion reduced blood chromium concentrations by two-thirds. The total quantities of chromium absorbed and removed by various routes were calculated. In-vitro studies showed that the chromium solution did not directly cause haemolysis.

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