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Excretion of cadmium through bile and intestinal wall in rats
  1. M. Cikrt,
  2. M. Tichý
  1. Institute of Hygiene and Epidemiology, Department of Industrial Hygiene and Occupational Diseases, Prague, Czechoslovakia

    Abstract

    Cikrt, M., and Tichý, M. (1974).British Journal of Industrial Medicine,31, 134-139. Excretion of cadmium through bile and intestinal wall in rats. The excretion of Cd2+ through the bile and intestinal wall after intravenous administration of CdCl2 in non-toxic doses (67, 90, and 120 μg of Cd2+ per rat) was studied in rats. The cumulative biliary excretion reached 24 hours after administration of the 67 μg dose was 0·83%, after 90 μg 1·18%, and after the 120 μg dose 5·68% of the amount given. The highest excretion rate of Cd2+ was detected between 15 and 30 minutes after administration. There was no difference in the excretion through intestinal wall between the 67 and 120 μg doses of Cd2+ per rat. The mean amount of cadmium found in the contents of the entire gastrointestinal tract and faeces was 5·5% of the administered dose. Using polyacrylamide gel disc electrophoresis it was found that Cd2+ is bound with at least two different components of the rat bile.

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