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Pharmacological prevention of acute ventilatory capacity reduction in flax dust exposure
  1. F. Valić,
  2. Eugenija Žuškin
  1. Andrija Štampar School of Public Health, Zagreb University, Zagreb, Yugoslavia

    Abstract

    Valić, F., and Žuškin, E. (1973).British Journal of Industrial Medicine,30, 381-384. Pharmacological prevention of acute ventilatory capacity reduction in flax dust exposure. The protective effect of the preshift application of a bronchodilator (orciprenaline), an antihistamine drug (diadril), and ascorbic acid on flax-induced acute bronchoconstriction was studied in 13 byssinotic and 7 non-byssinotic female workers exposed to airborne fibres of biologically retted flax. Orciprenaline was applied by inhalation, while diadril and ascorbic acid were given orally. All the three drugs exerted a significant preventive effect, diminishing the acute fall of ventilatory capacity during the shift. The fall in forced expiratory volume (FEV1·0) was reduced by 50% and the fall in maximal flow rate at 50% vital capacity (V̇max 50% VC) by over 65%.

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