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Excretion kinetics of urinary metabolites in a patient addicted to trichloroethylene
  1. Masayuki Ikeda1,
  2. Hatsue Ohtsuji1,
  3. Hitoshi Kawai2,
  4. Masichi Kuniyoshi3
  1. aKyoto University Faculty of Medicine and Higashiyama-Kogen Sanatorium, Kyoto, Japan

    Abstract

    Ikeda, M., Ohtsuji, H., Kawai, H., and Kuniyoshi, M. (1971).Brit. J. industr. Med.,28, 203-206. Excretion kinetics of urinary metabolites in a patient addicted to trichlorethylene. A male Japanese subject, single, aged 38, who worked at a workshop washing metal parts with trichloroethylene, was admitted to our clinic due to addiction to the solvent. Analyses of urine revealed the presence of up to 160 μg/ml of trichloro-compounds (mostly trichloroacetic acid) which gradually disappeared in three weeks as the psychotic symptoms cleared up. The excretion half-lives of trichloroethylene metabolites for the initial rapid phase (succeeding slow phase in parentheses) were 5·8 (49·7) hours for trichloroethanol, 22·5 (72·6) hours for trichloroacetic acid, and 7·5 (72·6) hours for total trichloro-compounds.

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    Footnotes

    • 1 Department of Public Health, Kyoto University Faculty of Medicine, Kyoto, Japan.

    • 2 Department of Psychiatry, Kyoto University Hospital, Kyoto, Japan.

    • 3 Department of Psychiatry, Higashiyama-Kogen Sanatorium, Kyoto, Japan.

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