Clark, D. G., and Litchfield, M. H. (1969).Brit. J. industr. Med.,26, 150-155. Metabolism of ethylene glycol dinitrate (ethylene dinitrate) in the rat following repeated administration. The in vivo metabolism of ethylene glycol dinitrate (EGDN) following repeated administration in the rat, and the in vitro metabolism of EDGN and nitroglycerine following repeated administration in the rat and the dog have been studied. No changes were detected in the in vivo or in vitro metabolism after repeated injection, and the pattern of excretion of EGDN metabolites in the urine did not alter. It is suggested that the tolerance that develops to the cardiovascular effects of these compounds may be due to the changing influence of some physiological compensatory mechanisms rather than to any change in the pattern of metabolism.
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