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Urinary hydroxyproline excretion in coalworkers' pneumoconiosis
  1. H. Resnick,
  2. N. L. Lapp,
  3. W. K. C. Morgan
  1. Cardiopulmonary and Biochemistry Units of the Medical Research Section, Appalachian Laboratory for Occupational Respiratory Diseases, Morgantown, West Virginia
  2. Bureau of Disease Prevention and Environmental Control, National Center for Urban and Industrial Health, Public Health Service, U.S. Department of Health, Education and Welfare
  3. The Departments of Biochemistry and Medicine, University of West Virginia Medical School

    Abstract

    Resnick, H., Lapp, N. L., and Morgan, W. K. C. (1969).Brit. J. industr. Med.,26, 135-138. Urinary hydroxyproline excretion in coalworkers' pneumoconiosis. As there is an increased formation of one or all the fibrous proteins in coalworkers' pneumoconiosis, it was felt that a study of the turnover rate of these proteins might shed some light on the pathogenesis of the disease. Urinary hydroxyproline excretion was therefore studied in a group of miners, of whom 19 had simple pneumoconiosis and five had progressive massive fibrosis. No significant deviation from the normal was found.

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