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VALUE OF ED50 TESTING IN ASSESSING HAZARDS OF ACUTE POISONING BY CARBAMATES AND ORGANOPHOSPHATES
  1. M. Vandekar,
  2. E. Reiner,
  3. B. Svetličić*,
  4. T. Fajdetić
  1. Institute for Medical Research, Yugoslav Academy of Sciences and Arts, Zagreb, Yugoslavia

    Abstract

    It is shown from the kinetics of inhibition of cholinesterase by N-methylcarbamates and organophosphates that the LD50 dose is likely to be a much greater multiple of the dose causing signs of poisoning in 50% of the animals (the ED50) for the carbamates than for the organophosphates. The expected difference was demonstrated by a comparison of the LD50s and ED50s, intravenous and intramuscular, of five carbamates (2-isopropoxyphenyl N-methylcarbamate, 3-isopropylphenyl N-methylcarbamate, 6-chloro-3,4-xylyl N-methylcarbamate, 3,4,5-trimethylphenyl N-methylcarbamate, and 3-methyl-5-isopropylphenyl N-methylcarbamate) and two organophosphorus compounds (diethyl 4-nitrophenyl phosphate and dimethyl 4-nitrophenyl phosphate). The slightest evoked tremor was chosen as the most reliable sign of poisoning from which to estimate the ED50 values. Carbamates gave much greater LD50/ED50 ratios than organophosphorus compounds. It is likely that occupational exposure to carbamates will produce incapacitating symptoms at doses well below lethal levels.

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    Footnotes

    • * Present address: `A. Stampar' School of Public Health, Medical Faculty, University of Zagreb, Zagreb, Yugoslavia.

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