Article Text

PDF

Evaluation of Exposure to Nitrobenzene: Absorption of Nitrobenzene Vapour through Lungs and Excretion of p-Nitrophenol in Urine
  1. J. Salmowa,
  2. J. Piotrowski,
  3. U. Neuhorn
  1. Department of Industrial Toxicology, Institute of Industrial Medicine, Lodz, Wodna 40, Poland

    Abstract

    In order to obtain a quantitative test for measuring exposure to nitrobenzene, experiments on men were done, in which nitrobenzene vapours (5 to 30 μg./l.) were absorbed into the lungs only. During an exposure of six hours the retention of nitrobenzene in the lungs diminished from approximately 87 to 73%. p-Aminophenol was not detected in the urine by the method used. Another metabolite, p-nitrophenol, was estimated in the urine of the exposed subjects; the quantities present represented about 13% of the inhaled dose of nitrobenzene. It was found that the determination of p-nitrophenol in urine could be used as a quantitative test when a single exposure to nitrobenzene occurred with a precision of approximately ± 8 mg. nitrobenzene. p-Nitrophenol is excreted in urine very slowly and therefore it may accumulate in the body. To evaluate the results of the proposed test in the case of a repeated exposure further investigations are necessary.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.