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Letters
Diesel particulate exposure and diabetes mortality among workers in the Ontario construction trades
Correspondence to:
Dr M M Finkelstein, McMaster University and University of Toronto, Family Medicine Centre, Mt Sinai Hospital, 60 Murray Street, 4th Floor, Toronto, Ontario, Canada M5T 3L9; murray.finkelstein@utoronto.ca
| The first 150 words of the full text of this article appear below. |
The world is experiencing a burgeoning epidemic of diabetes associated with increased rates of overweight and obesity.1 Evidence has accumulated that obesity is associated with a state of chronic low-grade inflammation and that intracellular signalling pathways activated by inflammatory responses are associated with insulin resistance.2 3 Diesel exhaust particulate (DEP) has been shown to increase markers of systemic and pulmonary inflammatory response in volunteers4 and studies of human bronchial epithelial cells in vitro have suggested that DEP induces proinflammatory substances by activating their transcription.5
Heavy equipment operators (HEOs) are occupationally exposed to DEP. Should these exposures augment a state of chronic low-grade systemic inflammation, then these workers might be at increased risk of diabetes. In a previous analysis I found that HEOs were at increased risk of heart disease mortality in comparison with other construction workers in Ontario.6 The present analysis was undertaken to explore the hypothesis that DEP-exposed HEOs
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Occup. Environ. Med. 2008 65: 215-216.[Extract] [Full Text] [PDF]
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