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Letters
Trichloroethylene exposure and non-Hodgkin’s lymphoma: supportive evidence
1 Exponent, Inc, Wood Dale, IL, USA
Correspondence to:
Dr J Mandel, Exponent, Inc, 185 Hansen Court, Suite 100, Wood Dale, IL 60191, USA; mandelj@exponent.com
| The first 150 words of the full text of this article appear below. |
We appreciate the interest in our recent meta-analysis of occupational trichloroethylene (TCE) exposure and non-Hodgkin’s lymphoma (NHL) (Occup Environ Med 2007;64:352). Three criticisms were mentioned as being "serious limitations": (1) that the alternative descriptions of the Group I occupational cohort studies (multiple industry vs aerospace, incidence vs mortality and Europe vs US studies) should have been characterised and discussed a priori; (2) that mortality and incidence data should not be combined in a meta-analysis; and (3) our interpretation that the epidemiological data are not supportive of a causal relation is wrong and it is suggested that our analysis provides more evidence of a causal effect between TCE exposure and NHL. These criticisms, however, are not serious limitations and have little relevance in interpreting the meta-analysis findings. We also disagree that our meta-analysis provides further support for a causal association.
The author would have preferred that we
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